{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:52:57Z","timestamp":1793141577030,"version":"4.5.0"},"reference-count":53,"publisher":"National Academy of Sciences","issue":"33","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI009484"],"award-info":[{"award-number":["AI009484"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI099699"],"award-info":[{"award-number":["AI099699"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL117722"],"award-info":[{"award-number":["HL117722"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HL135294"],"award-info":[{"award-number":["HL135294"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["TR001114"],"award-info":[{"award-number":["TR001114"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI007036"],"award-info":[{"award-number":["AI007036"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN272201400048C"],"award-info":[{"award-number":["HHSN272201400048C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,8,14]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>T cell exhaustion and successful therapy to restore T cell function initially uncovered with lymphocytic choriomeningitis virus (LCMV) Clone (Cl) 13 infection is important for understanding and treating persistent viral infections and cancers in mice and humans. Here, we report that Cl 13 infection in multiple inbred mouse strains elicits opposite phenotypes: acute death in 7 to 9 d associated with a robust T cell response contrasted to suppression of T cell response leading to persistent infection with normal life span. Death was due to pulmonary vascular leakage of fluids and cells into the lung, leading to respiratory failure. Death can be aborted by blocking interferon-1 signaling or deleting CD8 T cells.<\/jats:p>","DOI":"10.1073\/pnas.1804674115","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T15:06:03Z","timestamp":1532963163000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":52,"title":["Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics"],"prefix":"10.1073","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0804-0501","authenticated-orcid":false,"given":"Michael B. A.","family":"Oldstone","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Ware","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy E.","family":"Horton","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan J.","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2066-4536","authenticated-orcid":false,"given":"Roberto","family":"Aiolfi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Medolago Ruggeri (MERU) Foundation\u2013Roon Research Center for Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Zarpellon","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Medolago Ruggeri (MERU) Foundation\u2013Roon Research Center for Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0807-1295","authenticated-orcid":false,"given":"Zaverio M.","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Medolago Ruggeri (MERU) Foundation\u2013Roon Research Center for Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.78.019869"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.02.008"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3862"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.9.1383"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.12.2205"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/321239a0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.0074"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.5.1719"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.2.521"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04444"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811139106"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1492"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061462"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.10.009"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.10.001"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1849"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.111.132639"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800098-4.00004-0"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1534\/g3.115.022087"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00493-15"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408148111"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011998107"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.04.010"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.4.1863-1869.1991"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(89)90163-3"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.9.1249"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019304108"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5396.2079"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200104103"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.11.023"},{"key":"e_1_3_3_31_2","first-page":"45","article-title":"The Non Obese Diabetic (NOD) mouse, as a model of T cell mediated autoimmune disease","volume":"314","author":"Bach JF","year":"1992","unstructured":"JF Bach, The Non Obese Diabetic (NOD) mouse, as a model of T cell mediated autoimmune disease. C R Acad Sci III 314, 45\u201346 (1992).","journal-title":"C R Acad Sci III"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00541"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12430"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.5936"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197509112931105"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197509182931204"},{"key":"e_1_3_3_37_2","first-page":"908","article-title":"Platelet ITAM signaling is critical for vascular integrity in inflammation","volume":"123","author":"Boulaftali Y","year":"2013","unstructured":"Y Boulaftali, , Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest 123, 908\u2013916 (2013).","journal-title":"J Clin Invest"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711200105"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.01.013"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.01.012"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx163.460"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb04321.x"},{"key":"e_1_3_3_43_2","first-page":"1791","volume-title":"Fields Virology","author":"Buchmeier MJ","year":"2007","unstructured":"MJ Buchmeier, JC de la Torre, CJ Peters, Arenaviridae: The virus and its replication. Fields Virology, eds DM Knipe, PM Howley (Williams & Wilkins, 5th Ed, Philadelphia), pp. 1791\u20131828 (2007).","edition":"5"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00475"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10624"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.10.5140-5146.2002"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)81810-M"},{"key":"e_1_3_3_48_2","first-page":"83","article-title":"Biology and pathogenesis of lymphocytic choriomeningitis virus infection","volume":"263","author":"Oldstone MBA","year":"2002","unstructured":"MBA Oldstone, Biology and pathogenesis of lymphocytic choriomeningitis virus infection. Curr Top Microbiol Immunol 263, 83\u2013117 (2002).","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_3_49_2","first-page":"75","article-title":"Lassa fever","volume":"262","author":"McCormick JB","year":"2002","unstructured":"JB McCormick, SP Fisher-Hoch, Lassa fever. Curr Top Microbiol Immunol 262, 75\u2013109 (2002).","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.005"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1114836108"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.04.005"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235214"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1804674115","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1804674115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T04:10:57Z","timestamp":1649823057000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1804674115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,30]]},"references-count":53,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2018,8,14]]}},"alternative-id":["10.1073\/pnas.1804674115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1804674115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,30]]},"assertion":[{"value":"2018-07-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}