{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:49:19Z","timestamp":1791316159433,"version":"4.3.1"},"reference-count":21,"publisher":"National Academy of Sciences","issue":"31","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,7,31]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Schwann cells (SCs), the ensheathing glia of the peripheral nervous system, promote nerve repair\/regeneration. Defects in these SC injury responses potentially contribute to the pathogenesis of diabetic neuropathy, the most prevalent form of peripheral neuropathy. Here, we show that O-GlcNAcylation, a posttranslational modification controlled by the metabolic state of the cell, influences SC injury responses and nerve repair. The transcription factor JUN, an essential regulator of the SC injury program, is O-GlcNAcylated at multiple sites, and loss of this modification leads to increased activity and ineffective repair SC function. These results demonstrate that O-GlcNAcylation regulates SC injury responses via modulation of JUN activity and broaden our understanding of how changes in metabolism, such as occur in diabetes, affect nerve repair.<\/jats:p>","DOI":"10.1073\/pnas.1805538115","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T15:05:57Z","timestamp":1531753557000},"page":"8019-8024","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN"],"prefix":"10.1073","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-2517","authenticated-orcid":false,"given":"Sungsu","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7838-5420","authenticated-orcid":false,"given":"Jason C.","family":"Maynard","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Strickland","sequence":"additional","affiliation":[{"name":"Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma L.","family":"Burlingame","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Milbrandt","sequence":"additional","affiliation":[{"name":"Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110;"},{"name":"Hope Center for Neurological Diseases, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1085-9489.2005.0010205.x","article-title":"Impaired peripheral nerve regeneration in diabetes mellitus","volume":"10","author":"Kennedy JM","year":"2005","unstructured":"JM Kennedy, DW Zochodne, Impaired peripheral nerve regeneration in diabetes mellitus. 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