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Mol Biol Cell 7, 1535\u20131546 (1996).","journal-title":"Mol Biol Cell"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1083\/jcb.201601090","article-title":"The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR","volume":"215","author":"Scharaw S","year":"2016","unstructured":"S Scharaw, , The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR. J Cell Biol 215, 543\u2013558 (2016).","journal-title":"J Cell Biol"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"14360","DOI":"10.1073\/pnas.1519333112","article-title":"Unique COPII component AtSar1a\/AtSec23a pair is required for the distinct function of protein ER export in Arabidopsis thaliana","volume":"112","author":"Zeng Y","year":"2015","unstructured":"Y Zeng, , Unique COPII component AtSar1a\/AtSec23a pair is required for the distinct function of protein ER export in Arabidopsis thaliana. Proc Natl Acad Sci USA 112, 14360\u201314365 (2015).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1182\/blood-2014-01-548305","article-title":"Global transcriptome analyses of human and murine terminal erythroid differentiation","volume":"123","author":"An X","year":"2014","unstructured":"X An, , Global transcriptome analyses of human and murine terminal erythroid differentiation. Blood 123, 3466\u20133477 (2014).","journal-title":"Blood"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1073\/pnas.1401598111","article-title":"Transcriptional divergence and conservation of human and mouse erythropoiesis","volume":"111","author":"Pishesha N","year":"2014","unstructured":"N Pishesha, , Transcriptional divergence and conservation of human and mouse erythropoiesis. Proc Natl Acad Sci USA 111, 4103\u20134108 (2014).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"e1004890","DOI":"10.1371\/journal.pgen.1004890","article-title":"Altered chromatin occupancy of master regulators underlies evolutionary divergence in the transcriptional landscape of erythroid differentiation","volume":"10","author":"Ulirsch JC","year":"2014","unstructured":"JC Ulirsch, , Altered chromatin occupancy of master regulators underlies evolutionary divergence in the transcriptional landscape of erythroid differentiation. PLoS Genet 10, e1004890 (2014).","journal-title":"PLoS Genet"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ajhg.2015.10.001","article-title":"Germline heterozygous variants in SEC23B are associated with Cowden syndrome and enriched in apparently sporadic thyroid cancer","volume":"97","author":"Yehia L","year":"2015","unstructured":"L Yehia, , Germline heterozygous variants in SEC23B are associated with Cowden syndrome and enriched in apparently sporadic thyroid cancer. Am J Hum Genet 97, 661\u2013676 (2015).","journal-title":"Am J Hum Genet"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nrg2482","article-title":"Turning a hobby into a job: How duplicated genes find new functions","volume":"9","author":"Conant GC","year":"2008","unstructured":"GC Conant, KH Wolfe, Turning a hobby into a job: How duplicated genes find new functions. Nat Rev Genet 9, 938\u2013950 (2008).","journal-title":"Nat Rev Genet"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.290.5494.1151","article-title":"The evolutionary fate and consequences of duplicate genes","volume":"290","author":"Lynch M","year":"2000","unstructured":"M Lynch, JS Conery, The evolutionary fate and consequences of duplicate genes. Science 290, 1151\u20131155 (2000).","journal-title":"Science"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nature06107","article-title":"Natural history and evolutionary principles of gene duplication in fungi","volume":"449","author":"Wapinski I","year":"2007","unstructured":"I Wapinski, A Pfeffer, N Friedman, A Regev, Natural history and evolutionary principles of gene duplication in fungi. Nature 449, 54\u201361 (2007).","journal-title":"Nature"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1126\/science.aad8411","article-title":"Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals","volume":"352","author":"Lan X","year":"2016","unstructured":"X Lan, JK Pritchard, Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals. Science 352, 1009\u20131013 (2016).","journal-title":"Science"},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1242\/dev.127.17.3703","article-title":"Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development","volume":"127","author":"Bouchard M","year":"2000","unstructured":"M Bouchard, P Pfeffer, M Busslinger, Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development. Development 127, 3703\u20133713 (2000).","journal-title":"Development"},{"key":"e_1_3_4_47_2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35001077","article-title":"Maintenance of functional equivalence during paralogous Hox gene evolution","volume":"403","author":"Greer JM","year":"2000","unstructured":"JM Greer, J Puetz, KR Thomas, MR Capecchi, Maintenance of functional equivalence during paralogous Hox gene evolution. Nature 403, 661\u2013665 (2000).","journal-title":"Nature"},{"key":"e_1_3_4_48_2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.7624797","article-title":"Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2","volume":"269","author":"Hanks M","year":"1995","unstructured":"M Hanks, W Wurst, L Anson-Cartwright, AB Auerbach, AL Joyner, Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269, 679\u2013682 (1995).","journal-title":"Science"},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1101\/gad.14.11.1390","article-title":"N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation","volume":"14","author":"Malynn BA","year":"2000","unstructured":"BA Malynn, , N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev 14, 1390\u20131399 (2000).","journal-title":"Genes Dev"},{"key":"e_1_3_4_50_2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.devcel.2007.10.005","article-title":"The genetic basis of a craniofacial disease provides insight into COPII coat assembly","volume":"13","author":"Fromme JC","year":"2007","unstructured":"JC Fromme, , The genetic basis of a craniofacial disease provides insight into COPII coat assembly. Dev Cell 13, 623\u2013634 (2007).","journal-title":"Dev Cell"},{"key":"e_1_3_4_51_2","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/29325","article-title":"A dual thrombin receptor system for platelet activation","volume":"394","author":"Kahn ML","year":"1998","unstructured":"ML Kahn, , A dual thrombin receptor system for platelet activation. Nature 394, 690\u2013694 (1998).","journal-title":"Nature"},{"key":"e_1_3_4_52_2","doi-asserted-by":"crossref","first-page":"e19760","DOI":"10.7554\/eLife.19760","article-title":"Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation","volume":"5","author":"Horlbeck MA","year":"2016","unstructured":"MA Horlbeck, , Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. eLife 5, e19760 (2016).","journal-title":"eLife"},{"key":"e_1_3_4_53_2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nature14136","article-title":"Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex","volume":"517","author":"Konermann S","year":"2015","unstructured":"S Konermann, , Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature 517, 583\u2013588 (2015).","journal-title":"Nature"},{"key":"e_1_3_4_54_2","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.cell.2017.10.025","article-title":"In vivo target gene activation via CRISPR\/Cas9-mediated trans-epigenetic modulation","volume":"171","author":"Liao HK","year":"2017","unstructured":"HK Liao, , In vivo target gene activation via CRISPR\/Cas9-mediated trans-epigenetic modulation. Cell 171, 1495\u20131507.e15 (2017).","journal-title":"Cell"},{"key":"e_1_3_4_55_2","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nm.4170","article-title":"A genome-editing strategy to treat \u03b2-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition","volume":"22","author":"Traxler EA","year":"2016","unstructured":"EA Traxler, , A genome-editing strategy to treat \u03b2-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition. Nat Med 22, 987\u2013990 (2016).","journal-title":"Nat Med"},{"key":"e_1_3_4_56_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jprot.2014.09.011","article-title":"Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes","volume":"118","author":"Lambert JP","year":"2015","unstructured":"JP Lambert, M Tucholska, C Go, JD Knight, AC Gingras, Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. J Proteomics 118, 81\u201394 (2015).","journal-title":"J Proteomics"},{"key":"e_1_3_4_57_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-4939-6747-6_10","article-title":"Parallel exploration of interaction space by BioID and affinity purification coupled to mass spectrometry","volume":"1550","author":"Hesketh GG","year":"2017","unstructured":"GG Hesketh, JY Youn, P Samavarchi-Tehrani, B Raught, AC Gingras, Parallel exploration of interaction space by BioID and affinity purification coupled to mass spectrometry. Methods Mol Biol 1550, 115\u2013136 (2017).","journal-title":"Methods Mol Biol"},{"key":"e_1_3_4_58_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nbt.1832","article-title":"Systematic exploration of essential yeast gene function with temperature-sensitive mutants","volume":"29","author":"Li Z","year":"2011","unstructured":"Z Li, , Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol 29, 361\u2013367 (2011).","journal-title":"Nat Biotechnol"},{"key":"e_1_3_4_59_2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe K","year":"2013","unstructured":"K Howe, , The zebrafish reference genome sequence and its relationship to the human genome. Nature 496, 498\u2013503, and erratum (2014) 505:248 (2013).","journal-title":"Nature"},{"key":"e_1_3_4_60_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nbt.2501","article-title":"Efficient genome editing in zebrafish using a CRISPR-Cas system","volume":"31","author":"Hwang WY","year":"2013","unstructured":"WY Hwang, , Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol 31, 227\u2013229 (2013).","journal-title":"Nat Biotechnol"},{"key":"e_1_3_4_61_2","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1182\/blood-2017-02-765206","article-title":"Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway","volume":"130","author":"Hu Z","year":"2017","unstructured":"Z Hu, , Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway. Blood 130, 666\u2013676 (2017).","journal-title":"Blood"},{"key":"e_1_3_4_62_2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10163","article-title":"A conditional knockout resource for the genome-wide study of mouse gene function","volume":"474","author":"Skarnes WC","year":"2011","unstructured":"WC Skarnes, , A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474, 337\u2013342 (2011).","journal-title":"Nature"},{"key":"e_1_3_4_63_2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nmeth.1521","article-title":"Dual RMCE for efficient re-engineering of mouse mutant alleles","volume":"7","author":"Osterwalder M","year":"2010","unstructured":"M Osterwalder, , Dual RMCE for efficient re-engineering of mouse mutant alleles. Nat Methods 7, 893\u2013895 (2010).","journal-title":"Nat Methods"},{"key":"e_1_3_4_64_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-1-4939-7428-3_2","article-title":"Using the zebrafish as an approach to examine the mechanisms of vertebrate erythropoiesis","volume":"1698","author":"Kafina MD","year":"2018","unstructured":"MD Kafina, BH Paw, Using the zebrafish as an approach to examine the mechanisms of vertebrate erythropoiesis. Methods Mol Biol 1698, 11\u201336 (2018).","journal-title":"Methods Mol Biol"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1805784115","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1805784115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T14:14:32Z","timestamp":1654611272000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1805784115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,31]]},"references-count":64,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2018,8,14]]}},"alternative-id":["10.1073\/pnas.1805784115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1805784115","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/215160","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,31]]},"assertion":[{"value":"2018-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}