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U.S.A."],"published-print":{"date-parts":[[2019,2,26]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Noonan syndrome belongs to a group of related developmental disorders termed the RASopathies, and both the M-Ras GTPase and its effector Shoc2 are signaling proteins mutated in specific subtypes of this disorder. Previously, the M-Ras\/Shoc2 complex has been shown to act as a positive regulator of growth factor-mediated ERK cascade activation, and, here, we demonstrate a function for M-Ras\/Shoc2\/ERK cascade signaling in the dynamic control of cell\u2013cell adhesion that is required for collective cell migration. Given the essential role of collective cell migration in human embryogenesis and organ development, our elucidation of M-Ras\/Shoc2 function in this highly regulated process may provide insight regarding the cellular basis of defects associated with Noonan syndrome and other RASopathies.<\/jats:p>","DOI":"10.1073\/pnas.1805919116","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T20:37:59Z","timestamp":1549917479000},"page":"3536-3545","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":37,"title":["M-Ras\/Shoc2 signaling modulates E-cadherin turnover and cell\u2013cell adhesion during collective cell migration"],"prefix":"10.1073","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2825-5123","authenticated-orcid":false,"given":"Pradeep","family":"Kota","sequence":"first","affiliation":[{"name":"Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Terrell","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Ritt","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Insinna","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Westlake","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-1987","authenticated-orcid":false,"given":"Deborah K.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2720"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2015.14"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092053"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-04-0277"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.145.5.1077"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.10.004"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201674"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.12.6794"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.03.027"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005327200"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105760200"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.34.23850"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.91225"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.425"},{"key":"e_1_3_3_15_2","first-page":"1290","article-title":"A novel SHOC2 variant in rasopathy","volume":"35","author":"Hannig V","year":"2014","unstructured":"V Hannig, M Jeoung, ER Jang, 3rd JA Phillips, E Galperin, A novel SHOC2 variant in rasopathy. 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