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These conditions include examples from systemic lupus erythematosus, Aicardi\u2013Gouti\u00e9res syndrome, and STING-associated vasculopathy with onset in infancy. The involvement of STING in these diseases points to an unmet demand to identify inhibitors of STING signaling, which could form the basis of anti-STING therapeutics. With this report, we identify distinct endogenously formed lipid species as potent inhibitors of STING signaling\u2014and propose that these lipids could have pharmaceutical potential for treatment of STING-dependent inflammatory diseases.<\/jats:p>","DOI":"10.1073\/pnas.1806239115","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T15:06:19Z","timestamp":1532963179000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":294,"title":["Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling"],"prefix":"10.1073","volume":"115","author":[{"given":"Anne Louise","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory 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