{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:09:00Z","timestamp":1790680140060,"version":"4.1.0"},"reference-count":61,"publisher":"National Academy of Sciences","issue":"38","license":[{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Ministry of Science and Culture, Lower Saxony, Germany","award":["N-RENNT"],"award-info":[{"award-number":["N-RENNT"]}]},{"name":"Hemholtz Zukunftsthema Immunology & Inflammation","award":["Immunology & Inflammation"],"award-info":[{"award-number":["Immunology & Inflammation"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,9,18]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Viral encephalitis is a frequent medical emergency, often resulting in acute seizures and brain damage, which reduce quality of life, promote the development of epilepsy, and can cause death. The relative roles of activation of microglia, the brain-resident innate immune cells, versus invasion of blood-borne immune cells such as monocytes in the acute and chronic consequences of viral encephalitis are only incompletely understood. Here we show that lack of the chemokine receptors CCR2 or CX3CR1, which regulate the responses of myeloid cells such as monocytes and microglia, prevents hippocampal damage but not seizures in a mouse model of viral encephalitis. Treatment strategies aimed at inhibiting peripheral immune cells from entering the brain during encephalitis could reduce brain damage.<\/jats:p>","DOI":"10.1073\/pnas.1806754115","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T12:46:04Z","timestamp":1536065164000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":61,"title":["Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures"],"prefix":"10.1073","volume":"115","author":[{"given":"Christopher","family":"K\u00e4ufer","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, 30559 Hannover, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintan","family":"Chhatbar","sequence":"additional","affiliation":[{"name":"Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany, and the Hannover Medical School, 30625 Hannover, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Br\u00f6er","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, 30559 Hannover, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inken","family":"Waltl","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, 30559 Hannover, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ghita","sequence":"additional","affiliation":[{"name":"Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany, and the Hannover Medical School, 30625 Hannover, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Gerhauser","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Kalinke","sequence":"additional","affiliation":[{"name":"Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany, and the Hannover Medical School, 30625 Hannover, Germany;"},{"name":"Center for Systems Neuroscience, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9648-8973","authenticated-orcid":false,"given":"Wolfgang","family":"L\u00f6scher","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, 30559 Hannover, Germany;"},{"name":"Center for Systems Neuroscience, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,9,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13965"},{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"a022699","DOI":"10.1101\/cshperspect.a022699","article-title":"Immunity and inflammation in epilepsy","volume":"6","author":"Vezzani A","year":"2015","unstructured":"A Vezzani, B Lang, E Aronica, Immunity and inflammation in epilepsy. Cold Spring Harb Perspect Med 6, a022699 (2015).","journal-title":"Cold Spring Harb Perspect Med"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1481-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4475"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09615"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2923"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080421"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-1015-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.05.015"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.120"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604263113"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep00545"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-50"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02747-12"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.12.001"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2006.0068"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3531"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3423"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29919"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-170787"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.02.012"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00249"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.011"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.4.942-964.2004"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlw008"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn2014"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132477"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20124"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.11.054"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(72)90177-0"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.081126"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02390.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep28699"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2012.01256.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.11.107"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00027-7"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181ffc420"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00458-11"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13577"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23007"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.08.012"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6210-10.2011"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx001"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.178"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010814-124607"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13783"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2405-14.2015"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.14"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12354"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00121"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm3012273"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316510111"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.22.12053"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.11.4106-4114.2000"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.02.011"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.12.020"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.06.005"},{"key":"e_1_3_3_58_2","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2012","unstructured":"G Paxinos, KBJ Franklin The Mouse Brain in Stereotaxic Coordinates (Academic, 4th Ed, New York, 2012).","edition":"4"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.03.014"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.04.036"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2009.04.030"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1806754115","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1806754115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T04:15:45Z","timestamp":1649823345000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1806754115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,4]]},"references-count":61,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2018,9,18]]}},"alternative-id":["10.1073\/pnas.1806754115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1806754115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,4]]},"assertion":[{"value":"2018-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}