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U.S.A."],"published-print":{"date-parts":[[2018,10,9]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The molecular basis of the mysterious ability of the clinically approved bioresorbable vascular scaffold to maintain radial strength after 9 mo of hydrolysis\u2014despite a \u223c40% reduction in the poly\n                    <jats:sc>l<\/jats:sc>\n                    -lactide molecular weight\n                    <jats:italic>Mn<\/jats:italic>\n                    \u2014is an unexpected gradient in degradation revealed by X-ray microdiffraction. Hydrolysis is slowest in the 100- \u00d7 30-\u00b5m region where stress is concentrated during arterial contractions. This favorable gradient in hydrolysis arises from gradients in morphology created during crimping onto the angioplasty balloon: Small regions that undergo elongational deformation (&lt;3% of scaffold) resist hydrolysis after deployment. This remarkably small amount of material (too low to detect in\n                    <jats:italic>Mn<\/jats:italic>\n                    measurements) has a disproportionate impact on strength because it forms precisely where the scaffold is most vulnerable to failure.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1807347115","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T15:16:19Z","timestamp":1537197379000},"page":"10239-10244","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":19,"title":["Crimping-induced structural gradients explain the lasting strength of poly\n                    <scp>l<\/scp>\n                    -lactide bioresorbable vascular scaffolds during hydrolysis"],"prefix":"10.1073","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1820-7555","authenticated-orcid":false,"given":"Karthik","family":"Ramachandran","sequence":"first","affiliation":[{"name":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8947-0655","authenticated-orcid":false,"given":"Tiziana","family":"Di Luccio","sequence":"additional","affiliation":[{"name":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125;"},{"name":"Division of Sustainable Materials, ENEA Centro Ricerche Portici, I-80055 Portici, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artemis","family":"Ailianou","sequence":"additional","affiliation":[{"name":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"Kossuth","sequence":"additional","affiliation":[{"name":"Global Product Development, Abbott Vascular, Santa Clara, CA 95054"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Oberhauser","sequence":"additional","affiliation":[{"name":"Global Product Development, Abbott Vascular, Santa Clara, CA 95054"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Kornfield","sequence":"additional","affiliation":[{"name":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,9,17]]},"reference":[{"key":"e_1_3_3_1_2","volume-title":"Global Atlas on Cardiovascular Disease Prevention and Control","author":"WHO","year":"2010","unstructured":"; WHO Global Atlas on Cardiovascular Disease Prevention and Control (WHO, Geneva, 2010)."},{"key":"e_1_3_3_2_2","unstructured":"; National Center for Health Statistics Health United States 2016: With chartbook on long-term trends in health (US Department of Health and Human Services Washington DC) DHHS Publ No 2017-1232 pp 18 128\u2013131. 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