{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:59:40Z","timestamp":1789131580832,"version":"build-2803163510"},"reference-count":29,"publisher":"National Academy of Sciences","issue":"41","license":[{"start":{"date-parts":[[2019,3,24]],"date-time":"2019-03-24T00:00:00Z","timestamp":1553385600000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["MEXT-Supported Program for the Strategic Research Foundation at Private Universities S1311035"],"award-info":[{"award-number":["MEXT-Supported Program for the Strategic Research Foundation at Private Universities S1311035"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,10,9]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Delivery of most drug carriers to the kidney is limited because of their uptake by the reticuloendothelial system in the liver and spleen. We have developed\n                    <jats:sc>l<\/jats:sc>\n                    -serine (Ser)\u2013modified polyamidoamine dendrimer (PAMAM) as a potent renal targeting drug carrier for the treatment of kidney diseases. Pharmacokinetic and single-photon emission computed tomography\/computed tomography studies indicated that Ser modification results in efficient kidney targeting of PAMAM. Ser-PAMAM accumulated predominantly in proximal tubules, a pattern associated with the pathogenesis of renal cell carcinoma and chronic renal failure. Efficient renal distribution and pharmacologic effect of captopril was observed after i.v. injection of the Ser-PAMAM-captopril conjugate. Thus, our results demonstrate successful kidney targeting of a drug carrier via Ser modification.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1808168115","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T15:04:43Z","timestamp":1537801483000},"page":"10511-10516","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":76,"title":["<scp>l<\/scp>\n                    -Serine\u2013modified polyamidoamine dendrimer as a highly potent renal targeting drug carrier"],"prefix":"10.1073","volume":"115","author":[{"given":"Satoru","family":"Matsuura","sequence":"first","affiliation":[{"name":"Department of Biopharmaceutics, Kyoto Pharmaceutical University, 607-8414 Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemasa","family":"Katsumi","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Kyoto Pharmaceutical University, 607-8414 Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroe","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Kyoto Pharmaceutical University, 607-8414 Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Kyoto Pharmaceutical University, 607-8414 Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Kyoto Pharmaceutical University, 607-8414 Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Koshino","sequence":"additional","affiliation":[{"name":"Department of Bio-Medical Imaging, National Cerebral and Cardiovascular Center Research Institute, 565-8565 Osaka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Bio-Medical Imaging, National Cerebral and Cardiovascular Center Research Institute, 565-8565 Osaka, Japan;"},{"name":"Department of Nuclear Medicine, Wuerzburg University, 97080 Wuerzburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 607-8414 Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 607-8414 Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyasu","family":"Sakane","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Kyoto Pharmaceutical University, 607-8414 Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics, Kyoto Pharmaceutical University, 607-8414 Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,9,24]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2063193"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1929.9.3.399"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-690X(03)00049-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/S0022-3565(25)10645-9","article-title":"Targeting 6-thioguanine to the kidney with S-(guanin-6-yl)-L-cysteine","volume":"274","author":"Elfarra AA","year":"1995","unstructured":"AA Elfarra, RJ Duescher, IY Hwang, AR Sicuri, JA Nelson, Targeting 6-thioguanine to the kidney with S-(guanin-6-yl)-L-cysteine. 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