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However, it remains unclear how folate deficiency could be a causative factor in such a diverse range of disorders. Through analysis of the\n                    <jats:italic>FRAXA<\/jats:italic>\n                    locus, which contains an extensive CGG repeat sequence, we show that folate deprivation triggers extensive mitotic missegregation of the locus. Moreover, the entire chromosome X becomes unstable during a period of long-term folate deprivation. Considering that the human genome contains several loci associated with extensive CGG repeat regions, these findings suggest a mechanism by which folate deficiency contributes to the onset of a wide range of human diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1808377115","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T20:15:32Z","timestamp":1543868132000},"page":"13003-13008","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":32,"title":["Folate deficiency drives mitotic missegregation of the human\n                    <i>FRAXA<\/i>\n                    locus"],"prefix":"10.1073","volume":"115","author":[{"given":"Victoria A.","family":"Bjerregaard","sequence":"first","affiliation":[{"name":"Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Garribba","sequence":"additional","affiliation":[{"name":"Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia T.","family":"McMurray","sequence":"additional","affiliation":[{"name":"Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"Hickson","sequence":"additional","affiliation":[{"name":"Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark;"},{"name":"Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3703-2498","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.41.042007.165900"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2006.05.010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000072840"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506497102"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1882"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.041"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2201"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.02.025"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.04.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml054"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21193"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj347"},{"key":"e_1_3_3_13_2","first-page":"1055","article-title":"Nutrient intake and risk of subtypes of esophageal and gastric cancer","volume":"10","author":"Mayne ST","year":"2001","unstructured":"ST Mayne, , Nutrient intake and risk of subtypes of esophageal and gastric cancer. 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