{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:43:16Z","timestamp":1781109796180,"version":"3.54.1"},"reference-count":79,"publisher":"National Academy of Sciences","issue":"40","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS094009"],"award-info":[{"award-number":["NS094009"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,10,2]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Although large ensembles of neurons have been found to change as a function of learning and memory, localizing those changes to the individual neurons directly involved in a specific task has been challenging. Using whole-cell recording of deep cerebellar nuclear neurons (DCN) and a transsynaptic viral tracer, we found motor learning induced significant changes in membrane properties of rat DCN projection neurons including a reduced after-hyperpolarization amplitude and shortened latency for both evoked DCN action potentials and rebound spikes. These learning-specific changes in DCN excitability have not previously been reported in any species or task.<\/jats:p>","DOI":"10.1073\/pnas.1808539115","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T13:25:22Z","timestamp":1535462722000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":14,"title":["Changes in membrane properties of rat deep cerebellar nuclear projection neurons during acquisition of eyeblink conditioning"],"prefix":"10.1073","volume":"115","author":[{"given":"Desheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Department of Neuroscience, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV 26506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie A.","family":"Smith-Bell","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Department of Neuroscience, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV 26506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren B.","family":"Burhans","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Department of Neuroscience, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV 26506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deidre E.","family":"O\u2019Dell","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Department of Neuroscience, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV 26506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger W.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Department of Neuroscience, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV 26506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard G.","family":"Schreurs","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Department of Neuroscience, West Virginia University School of Medicine, Morgantown, WV 26506;"},{"name":"Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV 26506"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,8,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01547-4"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.138.3536.33"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-14-05498.1998"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.106.4.657"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.59603"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.118.5.1111"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00181-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/72049"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.05.021"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2061-08.2008"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018822"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.055814"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2013.00133"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-02-00813.2000"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1534582304265865"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22203"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712006105"},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/dev.21204","article-title":"Sensory system development influences the ontogeny of eyeblink conditioning","volume":"56","author":"Goldsberry ME","year":"2014","unstructured":"ME Goldsberry, ME Elkin, JH Freeman, Sensory system development influences the ontogeny of eyeblink conditioning. Dev Psychobiol 56, 1244\u20131251 (2014).","journal-title":"Dev Psychobiol"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1131208"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.01.076"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4534-04.2005"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.91105"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6701513"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-11-02811.1984"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6021428"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00048"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-004-1246-9"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2088-12.2012"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0284-12.2012"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0031298"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-20-08808.2002"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.12.017"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01043.2002"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb15736.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907118107"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2302(200003)36:2<148::AID-DEV6>3.0.CO;2-L"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0076-6"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1989.61.5.971"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.8.2733"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10081-3"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.10.057"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28132"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3226-10.2010"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3464-16.2017"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.09.007"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2013.07.008"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-14-05476.2000"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-17-05536.1996"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01177.2002"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-05-01814.1999"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22005"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi125"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202483399"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-009-0140-6"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-010-0240-3"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227987"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0384-09.2009"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4068-12.2013"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0193-15.2015"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1365609"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6494926"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.4.1697"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2012.00097"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-009-0153-1"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.31.3.209"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2623-07.2008"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2329-15.2015"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.18.10106-10112.2003"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02701.2002"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000640"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.9264"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90370-4"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.10.020"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311062110"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006923"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-02-00391.1986"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.05.090"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.06.049"},{"key":"e_1_3_3_79_2","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2005","unstructured":"G Paxinos, C Watson The Rat Brain in Stereotaxic Coordinates (Academic, 5th Ed, Burlington, MA, 2005).","edition":"5"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1808539115","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1808539115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T14:08:12Z","timestamp":1720534092000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1808539115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,28]]},"references-count":79,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2018,10,2]]}},"alternative-id":["10.1073\/pnas.1808539115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1808539115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,28]]},"assertion":[{"value":"2018-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}