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The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway has also been implicated in regulating stem cell functions in multiple tissue types. However, the crosstalk between these two pathways remains largely unclear. Herein, using in vitro cell lines, ex vivo organoids, and an in vivo mouse model, we made striking findings in support of a paradigm that mTORC1 signaling cell autonomously suppresses Wnt\/\u03b2-catenin signaling through down-regulating the Wnt receptor FZD level to influence stem cell functions, with implications in the aging process.<\/jats:p>","DOI":"10.1073\/pnas.1808575115","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T15:14:11Z","timestamp":1539011651000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":75,"title":["mTORC1 signaling suppresses Wnt\/\u03b2-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level"],"prefix":"10.1073","volume":"115","author":[{"given":"Hao","family":"Zeng","sequence":"first","affiliation":[{"name":"Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Cambridge, MA 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