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Invasion of cells through basement membrane barriers is a key aspect of many normal and pathological processes, including organ development and cancer cell metastasis. Invasive protrusions are rich in actin, a cytoskeletal biopolymer, the self-assembly of which can produce force and remodel extracellular matrix. However, in the invasive protrusion, actin has been attributed a function in scaffolding and trafficking, and its mechanical role has not been explored. Here we show that invading cells in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    apply forces via actin assembly to break through basement membrane, and that force production is one of the key features of invasion.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1808760115","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T15:30:07Z","timestamp":1540222207000},"page":"11537-11542","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":39,"title":["Forces drive basement membrane invasion in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1073","volume":"115","author":[{"given":"Rodrigo","family":"C\u00e1ceres","sequence":"first","affiliation":[{"name":"Laboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, 75005 Paris, France;"},{"name":"Universit\u00e9 Paris Descartes, 75005 Paris, France;"},{"name":"Sorbonne 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