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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,10,16]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Axon degeneration is caused by multiple chemotherapeutic agents and is a hallmark of chemotherapy-induced peripheral neuropathy (CIPN). CIPN is associated with the loss of the essential metabolite nicotinamide adenine dinucleotide (NAD\n                    <jats:sup>+<\/jats:sup>\n                    ), a vital metabolite involved in energy homeostasis, but whether NAD\n                    <jats:sup>+<\/jats:sup>\n                    loss or the accumulation of an NAD\n                    <jats:sup>+<\/jats:sup>\n                    precursor, nicotinamide mononucleotide (NMN), is responsible for axon degeneration is controversial. We found that axon degeneration caused by vincristine, a widely used chemotherapeutic agent, could be ameliorated by forcing peripheral neurons to use an NAD\n                    <jats:sup>+<\/jats:sup>\n                    biosynthetic pathway that bypasses NMN formation. This strategy provides an approach for preventing CIPN.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1809392115","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T16:05:59Z","timestamp":1537977959000},"page":"10654-10659","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":104,"title":["Pharmacological bypass of NAD\n                    <sup>+<\/sup>\n                    salvage pathway protects neurons from chemotherapy-induced degeneration"],"prefix":"10.1073","volume":"115","author":[{"given":"Hui-wen","family":"Liu","sequence":"first","affiliation":[{"name":"Vollum Institute, Oregon Health &amp; Science University, Portland, OR 97239;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadwick B.","family":"Smith","sequence":"additional","affiliation":[{"name":"Vollum Institute, Oregon Health &amp; Science University, Portland, OR 97239;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 55242;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu A.","family":"Cambronne","sequence":"additional","affiliation":[{"name":"Vollum Institute, Oregon Health &amp; 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