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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,10,9]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Human fungal pathogens resistant to conventional therapeutics pose a major threat to global human health. Thus, there is an urgent need to discover new antifungal drugs that act via novel mechanisms of action. Here, we show that commercial herbicides that inhibit acetohydroxyacid synthase (AHAS) have potent and broad-spectrum antifungal activity in vitro and that chlorimuron ethyl, a member of the sulfonylurea herbicide family, has antifungal activity in a mouse model. Thus, this study shows that AHAS inhibitors have strong potential to be developed into potent antifungal therapeutic agents.<\/jats:p>","DOI":"10.1073\/pnas.1809422115","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T15:06:09Z","timestamp":1537801569000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":74,"title":["Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections"],"prefix":"10.1073","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8378-7475","authenticated-orcid":false,"given":"Mario D.","family":"Garcia","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena M. 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