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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,10,23]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Cell adhesion molecules (CAMs) provide highly specific cell-surface recognition signals by which developing neurons interact with specific partners. However, these CAMs are common between neurons of the same type, and without a mechanism of self-avoidance or of homotypic avoidance, developing neurons will excessively adhere with themselves. This self-avoidance can be promoted by extreme molecular diversity, such as that of\n                    <jats:italic>Dscam1<\/jats:italic>\n                    (Down syndrome cell adhesion molecule 1) in flies, which gives neurons distinct barcodes. Mouse\n                    <jats:italic>Dscam,<\/jats:italic>\n                    on the other hand, promotes self-avoidance without molecular diversity. Here, we provide evidence that DSCAM can functionally interact with other CAMs, called cadherins and protocadherins, to act like a general \u201cnonstick\u201d signal. 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