{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:07:47Z","timestamp":1790611667774,"version":"4.1.0"},"reference-count":59,"publisher":"National Academy of Sciences","issue":"9","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21471068"],"award-info":[{"award-number":["21471068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21371081"],"award-info":[{"award-number":["21371081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1463474"],"award-info":[{"award-number":["1463474"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,2,26]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Engineering of reconfigurable nanoparticle assemblies enabled the practical realization of multiplexed detection, monitoring, and in vivo imaging of miRNA in live cells and animals, which was previously impeded by the fast degradation of these essential epigenetic markers. Nanoparticle superstructures afford rapid quantitative assessment of the imaging results, facilitating proliferation of digital personalized medicine.<\/jats:p>","DOI":"10.1073\/pnas.1810764116","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T20:41:22Z","timestamp":1549917682000},"page":"3391-3400","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":106,"title":["Quantitative zeptomolar imaging of miRNA cancer markers with nanoparticle assemblies"],"prefix":"10.1073","volume":"116","author":[{"given":"Aihua","family":"Qu","sequence":"first","affiliation":[{"name":"State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China;"},{"name":"International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu 214122, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maozhong","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China;"},{"name":"International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu 214122, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguang","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China;"},{"name":"International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu 214122, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlong","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China;"},{"name":"International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu 214122, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China;"},{"name":"International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu 214122, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5639-7102","authenticated-orcid":false,"given":"Chuanlai","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China;"},{"name":"International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu 214122, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6864-5804","authenticated-orcid":false,"given":"Nicholas A.","family":"Kotov","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Biointerface Institute, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Michigan Institute of Translational Nanotechnology, Ypsilanti, MI 48198"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Kuang","sequence":"additional","affiliation":[{"name":"State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China;"},{"name":"International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu 214122, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr300362f"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03702"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja308216z"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201305875"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn302633q"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b03617"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201503629"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201606086"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201703410"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0550-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac3004055"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10834"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b12845"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201702415"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201611641"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2013.08.010"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b05610"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b00697"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b01625"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b00725"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200901807"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp111006z"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b04007"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar300273v"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl015519n"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.200500198"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl051042u"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b00751"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201400323"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2013.309"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja2088713"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja207898r"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b02194"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.453"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200501264"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2012.10.006"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201612020"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b09474"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja5115248"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.7b03461"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2016.08.111"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201612142"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b07842"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201703408"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b10309"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201505023"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2014.12.021"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja3066336"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja209861x"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1602803"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3948"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b09349"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-4598"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn201369k"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1326"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707224200"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn4030898"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja4108287"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201503672"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1810764116","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1810764116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T04:10:24Z","timestamp":1649823024000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1810764116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,11]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,2,26]]}},"alternative-id":["10.1073\/pnas.1810764116"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1810764116","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,11]]},"assertion":[{"value":"2019-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}