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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,10,2]]},"abstract":"<jats:p>\n                    Intestinal epithelial cells (IECs) play a key role in regulating immune responses and controlling infection. However, the direct role of IECs in restricting pathogens remains incompletely understood. Here, we provide evidence that IL-22 primed intestinal organoids derived from healthy human induced pluripotent stem cells (hIPSCs) to restrict\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    serovar Typhimurium SL1344 infection. A combination of transcriptomics, bacterial invasion assays, and imaging suggests that IL-22\u2013induced antimicrobial activity is driven by increased phagolysosomal fusion in IL-22\u2013pretreated cells. The antimicrobial phenotype was absent in hIPSCs derived from a patient harboring a homozygous mutation in the\n                    <jats:italic>IL10RB<\/jats:italic>\n                    gene that inactivates the IL-22 receptor but was restored by genetically complementing the IL10RB deficiency. This study highlights a mechanism through which the IL-22 pathway facilitates the human intestinal epithelium to control microbial infection.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1811866115","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T15:27:35Z","timestamp":1536938855000},"page":"10118-10123","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":47,"title":["Interleukin-22 promotes phagolysosomal fusion to induce protection against\n                    <i>Salmonella enterica<\/i>\n                    Typhimurium in human epithelial cells"],"prefix":"10.1073","volume":"115","author":[{"given":"Jessica L.","family":"Forbester","sequence":"first","affiliation":[{"name":"Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom;"},{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Lees","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;"},{"name":"Department of Medicine, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge CB2 0QQ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goulding","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Forrest","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;"},{"name":"Department of Medicine, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge CB2 0QQ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Yeung","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4890-4685","authenticated-orcid":false,"given":"Anneliese","family":"Speak","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Clare","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve L.","family":"Coomber","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhankar","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9073-6318","authenticated-orcid":false,"given":"Judith","family":"Kraiczy","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Addenbrooke\u2019s Hospital, University of Cambridge, Cambridge CB2 0QQ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor D.","family":"Lawley","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E. 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