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U.S.A."],"published-print":{"date-parts":[[2019,6,25]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Development of new drugs from the venom of dangerous animals (spiders, snakes, scorpions, snails) has recently attracted much chemotherapeutic interest. While most isolated and characterized venom components are found to be proteinic or peptidic in nature, here we report two 1,4-benzoquinone compounds, one red and another blue, derived from the venom of a rarely studied scorpion (\n                    <jats:italic>Diplocentrus melici<\/jats:italic>\n                    ) indigenous to Mexico. After successful identification and synthesis of these compounds, the red and blue benzoquinones showed remarkable antimicrobial activities against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    , respectively. The observation that the blue compound is equally effective against normal and multidrug-resistant tuberculosis while appearing not to affect the epithelium of lungs heightens its potential as a new drug candidate.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1812334116","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T20:26:29Z","timestamp":1560198389000},"page":"12642-12647","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":49,"title":["1,4-Benzoquinone antimicrobial agents against\n                    <i>Staphylococcus aureus<\/i>\n                    and\n                    <i>Mycobacterium tuberculosis<\/i>\n                    derived from scorpion venom"],"prefix":"10.1073","volume":"116","author":[{"given":"Edson Norberto","family":"Carcamo-Noriega","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Bioprocesses, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, 62210 Morelos, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Sathyamoorthi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stanford University, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibdas","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stanford University, Stanford, CA 94305;"},{"name":"Department of Chemistry, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elumalai","family":"Gnanamani","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stanford University, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monserrat","family":"Mendoza-Trujillo","sequence":"additional","affiliation":[{"name":"Section of Experimental Pathology, Department of Pathology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n,\u201d 14080 Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce","family":"Mata-Espinosa","sequence":"additional","affiliation":[{"name":"Section of Experimental Pathology, Department of Pathology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n,\u201d 14080 Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Hern\u00e1ndez-Pando","sequence":"additional","affiliation":[{"name":"Section of Experimental Pathology, Department of Pathology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n,\u201d 14080 Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ignacio","family":"Veytia-Bucheli","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Bioprocesses, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, 62210 Morelos, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourival D.","family":"Possani","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Bioprocesses, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, 62210 Morelos, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5266-4253","authenticated-orcid":false,"given":"Richard N.","family":"Zare","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stanford University, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"key":"e_1_3_3_1_2","unstructured":"Epidemiolog\u00eda DGd \u201cManual de Procedimientos Estandarizados para la Vigilancia Epidemiol\u00f3gica de la Intoxicaci\u00f3n por Picadura de Alacr\u00e1n\u201d (Secretar\u00eda de Salud Salud SdPyPdl 2012)."},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S24754"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2009.01.020"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1975.sp010810"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.5.1782"},{"key":"e_1_3_3_6_2","first-page":"325","article-title":"Scorpion toxins: Chemistry and mode of action","volume":"3","author":"Rochat H.","year":"1979","unstructured":"H. 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