{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:41:22Z","timestamp":1787240482608,"version":"build-2736575974"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"42","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK036146"],"award-info":[{"award-number":["DK036146"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA210072"],"award-info":[{"award-number":["CA210072"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,10,16]]},"abstract":"<jats:p>\n                    Oxidatively induced DNA lesions 8,5\u2032-cyclopurine-2\u2032-deoxynucleosides (cdPus) are prevalent and cytotoxic by impeding DNA replication and transcription. Both the 5\u2032\n                    <jats:italic>R<\/jats:italic>\n                    - and 5\u2032\n                    <jats:italic>S<\/jats:italic>\n                    -diastereomers of cdPu can be removed by nucleotide excision repair; however, the 5\u2032\n                    <jats:italic>S<\/jats:italic>\n                    -cdPu is more resistant to repair than the 5\u2032\n                    <jats:italic>R<\/jats:italic>\n                    counterpart. Here, we report the crystal structures of human polymerase (Pol) \u03b7 bypassing 5\u2032\n                    <jats:italic>S<\/jats:italic>\n                    -8,5\u2032-cyclo-2\u2032-deoxyadenosine (cdA) in insertion and the following two extension steps. The cdA-containing DNA structures vary in response to the protein environment. Supported by the \u201cmolecular splint\u201d of Pol \u03b7, the structure of 5\u2032\n                    <jats:italic>S<\/jats:italic>\n                    -cdA at 1.75-\u00c5 resolution reveals that the backbone is pinched toward the minor groove and the adenine base is tilted. In the templating position, the cdA takes up the extra space usually reserved for the thymine dimer, and dTTP is efficiently incorporated by Pol \u03b7 in the presence of Mn\n                    <jats:sup>2+<\/jats:sup>\n                    . Rigid distortions of the DNA duplex by cdA, however, prevent normal base pairing and hinder immediate primer extension by Pol \u03b7. Our results provide structural insights into the strong replication blockage effect and the mutagenic property of the cdPu lesions in cells.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1812856115","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T15:07:07Z","timestamp":1538406427000},"page":"10660-10665","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":19,"title":["Bypassing a 8,5\u2032-cyclo-2\u2032-deoxyadenosine lesion by human DNA polymerase \u03b7 at atomic resolution"],"prefix":"10.1073","volume":"115","author":[{"given":"Peter J.","family":"Weng","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Gregory","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California, Riverside, CA 92521-0403"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of California, Riverside, CA 92521-0403"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3591-2195","authenticated-orcid":false,"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,10]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.dnarep.2008.06.005","article-title":"8,5\u2032-cyclopurine-2\u2032-deoxynucleosides in DNA: Mechanisms of formation, measurement, repair and biological effects","volume":"7","author":"Jaruga P","year":"2008","unstructured":"P Jaruga, M Dizdaroglu, 8,5\u2032-cyclopurine-2\u2032-deoxynucleosides in DNA: Mechanisms of formation, measurement, repair and biological effects. DNA Repair (Amst) 7, 1413\u20131425 (2008).","journal-title":"DNA Repair (Amst)"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2741\/4555","article-title":"Base excision repair of oxidative DNA damage: From mechanism to disease","volume":"22","author":"Whitaker AM","year":"2017","unstructured":"AM Whitaker, MA Schaich, MR Smith, TS Flynn, BD Freudenthal, Base excision repair of oxidative DNA damage: From mechanism to disease. Front Biosci 22, 1493\u20131522 (2017).","journal-title":"Front Biosci"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"22355","DOI":"10.1074\/jbc.M002259200","article-title":"The oxidative DNA lesion 8,5\u2032-(S)-cyclo-2\u2032-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells","volume":"275","author":"Brooks PJ","year":"2000","unstructured":"PJ Brooks, , The oxidative DNA lesion 8,5\u2032-(S)-cyclo-2\u2032-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells. J Biol Chem 275, 22355\u201322362 (2000).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1073\/pnas.070471597","article-title":"Removal of oxygen free-radical-induced 5\u2032,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells","volume":"97","author":"Kuraoka I","year":"2000","unstructured":"I Kuraoka, , Removal of oxygen free-radical-induced 5\u2032,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells. Proc Natl Acad Sci USA 97, 3832\u20133837 (2000).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.mad.2007.06.006","article-title":"The oxidatively induced DNA lesions 8,5\u2032-cyclo-2\u2032-deoxyadenosine and 8-hydroxy-2\u2032-deoxyadenosine are strongly resistant to acid-induced hydrolysis of the glycosidic bond","volume":"128","author":"Theruvathu JA","year":"2007","unstructured":"JA Theruvathu, P Jaruga, M Dizdaroglu, PJ Brooks, The oxidatively induced DNA lesions 8,5\u2032-cyclo-2\u2032-deoxyadenosine and 8-hydroxy-2\u2032-deoxyadenosine are strongly resistant to acid-induced hydrolysis of the glycosidic bond. Mech Ageing Dev 128, 494\u2013502 (2007).","journal-title":"Mech Ageing Dev"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1093\/nar\/gku162","article-title":"Structural basis for the recognition of diastereomeric 5\u2032,8-cyclo-2\u2032-deoxypurine lesions by the human nucleotide excision repair system","volume":"42","author":"Kropachev K","year":"2014","unstructured":"K Kropachev, , Structural basis for the recognition of diastereomeric 5\u2032,8-cyclo-2\u2032-deoxypurine lesions by the human nucleotide excision repair system. Nucleic Acids Res 42, 5020\u20135032 (2014).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/pro.723","article-title":"Surviving the sun: Repair and bypass of DNA UV lesions","volume":"20","author":"Yang W","year":"2011","unstructured":"W Yang, Surviving the sun: Repair and bypass of DNA UV lesions. Protein Sci 20, 1781\u20131789 (2011).","journal-title":"Protein Sci"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1474-9726.2012.00828.x","article-title":"The oxidative DNA lesions 8,5\u2032-cyclopurines accumulate with aging in a tissue-specific manner","volume":"11","author":"Wang J","year":"2012","unstructured":"J Wang, CL Clauson, PD Robbins, LJ Niedernhofer, Y Wang, The oxidative DNA lesions 8,5\u2032-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell 11, 714\u2013716 (2012).","journal-title":"Aging Cell"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/php.12239","article-title":"Quantitative and in situ detection of oxidatively generated DNA damage 8,5\u2032-cyclo-2\u2032-deoxyadenosine using an immunoassay with a novel monoclonal antibody","volume":"90","author":"Iwamoto T","year":"2014","unstructured":"T Iwamoto, , Quantitative and in situ detection of oxidatively generated DNA damage 8,5\u2032-cyclo-2\u2032-deoxyadenosine using an immunoassay with a novel monoclonal antibody. Photochem Photobiol 90, 829\u2013836 (2014).","journal-title":"Photochem Photobiol"},{"key":"e_1_3_4_10_2","first-page":"49283","article-title":"Oxygen free radical damage to DNA. Translesion synthesis by human DNA polymerase eta and resistance to exonuclease action at cyclopurine deoxynucleoside residues","volume":"276","author":"Kuraoka I","year":"2001","unstructured":"I Kuraoka, , Oxygen free radical damage to DNA. Translesion synthesis by human DNA polymerase eta and resistance to exonuclease action at cyclopurine deoxynucleoside residues. J Biol Chem 276, 49283\u201349288 (2001).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"E410","DOI":"10.1073\/pnas.1415186112","article-title":"Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions","volume":"112","author":"Walmacq C","year":"2015","unstructured":"C Walmacq, , Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. Proc Natl Acad Sci USA 112, E410\u2013E419 (2015).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"28548","DOI":"10.1074\/jbc.M113.480459","article-title":"Translesion synthesis of 8,5\u2032-cyclopurine-2\u2032-deoxynucleosides by DNA polymerases \u03b7, \u03b9, and \u03b6","volume":"288","author":"You C","year":"2013","unstructured":"C You, , Translesion synthesis of 8,5\u2032-cyclopurine-2\u2032-deoxynucleosides by DNA polymerases \u03b7, \u03b9, and \u03b6. J Biol Chem 288, 28548\u201328556 (2013).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1093\/nar\/gnh087","article-title":"Complete release of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyadenosine from dinucleotides, oligodeoxynucleotides and DNA, and direct comparison of its levels in cellular DNA with other oxidatively induced DNA lesions","volume":"32","author":"Jaruga P","year":"2004","unstructured":"P Jaruga, J Theruvathu, M Dizdaroglu, PJ Brooks, Complete release of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyadenosine from dinucleotides, oligodeoxynucleotides and DNA, and direct comparison of its levels in cellular DNA with other oxidatively induced DNA lesions. Nucleic Acids Res 32, e87 (2004).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2016.12.028","article-title":"The cyclopurine deoxynucleosides: DNA repair, biological effects, mechanistic insights, and unanswered questions","volume":"107","author":"Brooks PJ","year":"2017","unstructured":"PJ Brooks, The cyclopurine deoxynucleosides: DNA repair, biological effects, mechanistic insights, and unanswered questions. Free Radic Biol Med 107, 90\u2013100 (2017).","journal-title":"Free Radic Biol Med"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"20357","DOI":"10.1021\/ja207407n","article-title":"Structure of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyguanosine in DNA","volume":"133","author":"Huang H","year":"2011","unstructured":"H Huang, RS Das, AK Basu, MP Stone, Structure of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyguanosine in DNA. J Am Chem Soc 133, 20357\u201320368 (2011).","journal-title":"J Am Chem Soc"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1021\/tx2005053","article-title":"Structures of (5\u2032S)-8,5\u2032-Cyclo-2\u2032-deoxyguanosine mismatched with dA or dT","volume":"25","author":"Huang H","year":"2012","unstructured":"H Huang, RS Das, AK Basu, MP Stone, Structures of (5\u2032S)-8,5\u2032-Cyclo-2\u2032-deoxyguanosine mismatched with dA or dT. Chem Res Toxicol 25, 478\u2013490 (2012).","journal-title":"Chem Res Toxicol"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1021\/bi5014936","article-title":"Kinetic and structural mechanisms of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyguanosine-induced dna replication stalling","volume":"54","author":"Xu W","year":"2015","unstructured":"W Xu, , Kinetic and structural mechanisms of (5\u2032S)-8,5\u2032-cyclo-2\u2032-deoxyguanosine-induced dna replication stalling. Biochemistry 54, 639\u2013651 (2015).","journal-title":"Biochemistry"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1021\/tx3001576","article-title":"Accurate and efficient bypass of 8,5\u2032-cyclopurine-2\u2032-deoxynucleosides by human and yeast DNA polymerase \u03b7","volume":"25","author":"Swanson AL","year":"2012","unstructured":"AL Swanson, J Wang, Y Wang, Accurate and efficient bypass of 8,5\u2032-cyclopurine-2\u2032-deoxynucleosides by human and yeast DNA polymerase \u03b7. Chem Res Toxicol 25, 1682\u20131691 (2012).","journal-title":"Chem Res Toxicol"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/emboj.2008.281","article-title":"Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals","volume":"28","author":"Shachar S","year":"2009","unstructured":"S Shachar, , Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals. EMBO J 28, 383\u2013393 (2009).","journal-title":"EMBO J"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1073\/pnas.1324001111","article-title":"Human Pol \u03b6 purified with accessory subunits is active in translesion DNA synthesis and complements Pol \u03b7 in cisplatin bypass","volume":"111","author":"Lee YS","year":"2014","unstructured":"YS Lee, MT Gregory, W Yang, Human Pol \u03b6 purified with accessory subunits is active in translesion DNA synthesis and complements Pol \u03b7 in cisplatin bypass. Proc Natl Acad Sci USA 111, 2954\u20132959 (2014).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1021\/bi500019s","article-title":"An overview of Y-Family DNA polymerases and a case study of human DNA polymerase \u03b7","volume":"53","author":"Yang W","year":"2014","unstructured":"W Yang, An overview of Y-Family DNA polymerases and a case study of human DNA polymerase \u03b7. Biochemistry 53, 2793\u20132803 (2014).","journal-title":"Biochemistry"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.dnarep.2006.02.004","article-title":"Poor base stacking at DNA lesions may initiate recognition by many repair proteins","volume":"5","author":"Yang W","year":"2006","unstructured":"W Yang, Poor base stacking at DNA lesions may initiate recognition by many repair proteins. DNA Repair (Amst) 5, 654\u2013666 (2006).","journal-title":"DNA Repair (Amst)"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.cell.2009.11.043","article-title":"Structural insight into translesion synthesis by DNA Pol II","volume":"139","author":"Wang F","year":"2009","unstructured":"F Wang, W Yang, Structural insight into translesion synthesis by DNA Pol II. Cell 139, 1279\u20131289 (2009).","journal-title":"Cell"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nsmb.2985","article-title":"How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis","volume":"22","author":"Lee YS","year":"2015","unstructured":"YS Lee, Y Gao, W Yang, How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis. Nat Struct Mol Biol 22, 298\u2013303 (2015).","journal-title":"Nat Struct Mol Biol"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1021\/bi00549a031","article-title":"Enzyme-bound conformations of nucleotide substrates. X-ray structure and absolute configuration of 8,5\u2032-cycloadenosine monohydrate","volume":"19","author":"Haromy TP","year":"1980","unstructured":"TP Haromy, J Raleigh, M Sundaralingam, Enzyme-bound conformations of nucleotide substrates. X-ray structure and absolute configuration of 8,5\u2032-cycloadenosine monohydrate. Biochemistry 19, 1718\u20131722 (1980).","journal-title":"Biochemistry"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"8146","DOI":"10.1073\/pnas.1303126110","article-title":"Mechanism of somatic hypermutation at the WA motif by human DNA polymerase \u03b7","volume":"110","author":"Zhao Y","year":"2013","unstructured":"Y Zhao, , Mechanism of somatic hypermutation at the WA motif by human DNA polymerase \u03b7. Proc Natl Acad Sci USA 110, 8146\u20138151 (2013).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/nature09196","article-title":"Structure and mechanism of human DNA polymerase eta","volume":"465","author":"Biert\u00fcmpfel C","year":"2010","unstructured":"C Biert\u00fcmpfel, , Structure and mechanism of human DNA polymerase eta. Nature 465, 1044\u20131048 (2010).","journal-title":"Nature"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1073\/pnas.1202681109","article-title":"Structural basis of human DNA polymerase \u03b7-mediated chemoresistance to cisplatin","volume":"109","author":"Zhao Y","year":"2012","unstructured":"Y Zhao, , Structural basis of human DNA polymerase \u03b7-mediated chemoresistance to cisplatin. Proc Natl Acad Sci USA 109, 7269\u20137274 (2012).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"9133","DOI":"10.1073\/pnas.1405739111","article-title":"Structural and mechanistic studies of polymerase \u03b7 bypass of phenanthriplatin DNA damage","volume":"111","author":"Gregory MT","year":"2014","unstructured":"MT Gregory, , Structural and mechanistic studies of polymerase \u03b7 bypass of phenanthriplatin DNA damage. Proc Natl Acad Sci USA 111, 9133\u20139138 (2014).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"16867","DOI":"10.1074\/jbc.M114.551820","article-title":"Kinetics, structure, and mechanism of 8-Oxo-7,8-dihydro-2\u2032-deoxyguanosine bypass by human DNA polymerase \u03b7","volume":"289","author":"Patra A","year":"2014","unstructured":"A Patra, , Kinetics, structure, and mechanism of 8-Oxo-7,8-dihydro-2\u2032-deoxyguanosine bypass by human DNA polymerase \u03b7. J Biol Chem 289, 16867\u201316882 (2014).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nsmb1118","article-title":"Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota","volume":"13","author":"Nair DT","year":"2006","unstructured":"DT Nair, RE Johnson, L Prakash, S Prakash, AK Aggarwal, Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota. Nat Struct Mol Biol 13, 619\u2013625 (2006).","journal-title":"Nat Struct Mol Biol"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/emboj.2009.122","article-title":"Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota","volume":"28","author":"Kirouac KN","year":"2009","unstructured":"KN Kirouac, H Ling, Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota. EMBO J 28, 1644\u20131654 (2009).","journal-title":"EMBO J"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"15591","DOI":"10.1073\/pnas.0704219104","article-title":"What a difference a decade makes: Insights into translesion DNA synthesis","volume":"104","author":"Yang W","year":"2007","unstructured":"W Yang, R Woodgate, What a difference a decade makes: Insights into translesion DNA synthesis. Proc Natl Acad Sci USA 104, 15591\u201315598 (2007).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1126\/science.aad9633","article-title":"Capture of a third Mg2+ is essential for catalyzing DNA synthesis","volume":"352","author":"Gao Y","year":"2016","unstructured":"Y Gao, W Yang, Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science 352, 1334\u20131337 (2016).","journal-title":"Science"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"5945","DOI":"10.1093\/nar\/gkr159","article-title":"High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing","volume":"39","author":"Yuan B","year":"2011","unstructured":"B Yuan, J Wang, H Cao, R Sun, Y Wang, High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing. Nucleic Acids Res 39, 5945\u20135954 (2011).","journal-title":"Nucleic Acids Res"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1812856115","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1812856115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T19:05:18Z","timestamp":1720638318000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1812856115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":35,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2018,10,16]]}},"alternative-id":["10.1073\/pnas.1812856115"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1812856115","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"2018-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}