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U.S.A."],"published-print":{"date-parts":[[2019,2,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Tuberous sclerosis complex (TSC) is a genetic disease characterized by tumor formation in multiple organs. The identification of dysregulated cellular processes in TSC is necessary for the selection of possible therapeutic interventions. The current models place impaired mTORC1 signaling at the core of TSC pathogenesis. In this study, we identify an mTORC1-independent pathway that drives excess glycogen storage in TSC via impaired autophagic degradation of glycogen caused by defects in the autophagy-lysosome system. Importantly, we find that the combined use of mTORC1 and Akt pharmacological inhibitors restore glycogen homeostasis. 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