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The discoveries we report were made possible by using analytical tools more common in omics\/systems biology for functional and structural characterization, retasked for exploring and manipulating complex reaction networks. We not only demonstrate that environments can differentiate fixed sets of starting materials (both mixtures of pure amino acids and the classic Miller\u2013Urey \u201cprebiotic soup\u201d model), but that this has functional consequences. It has been often said that biology is \u201cchemistry with history\u201d and this work shows how this process can start.<\/jats:p>","DOI":"10.1073\/pnas.1813987116","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T19:35:24Z","timestamp":1551900924000},"page":"5387-5392","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":60,"title":["Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions"],"prefix":"10.1073","volume":"116","author":[{"given":"Andrew J.","family":"Surman","sequence":"first","affiliation":[{"name":"WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom G12 8QQ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Rodriguez-Garcia","sequence":"additional","affiliation":[{"name":"WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom G12 8QQ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-0653","authenticated-orcid":false,"given":"Yousef M.","family":"Abul-Haija","sequence":"additional","affiliation":[{"name":"WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom G12 8QQ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey J. 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