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We found primary and metastatic tumors to be remarkably similar and SBOC to be clonally related in all cases, suggesting early dissemination to represent an intrinsic feature of ovarian cancer. c-MYC and PIK3CA amplifications were prevalent and maintained in progression to metastasis and enriched in tumor recurrence. c-MYC amplified chemotherapy-resistant cell lines and xenografts were sensitive to JQ1 and GS-626510, suggesting Bromodomain and Extra-Terminal motif (BET) inhibitors as effective targeted agents in patients with c-MYC\u2013amplified recurrent\/chemotherapy-resistant ovarian tumors.<\/jats:p>","DOI":"10.1073\/pnas.1814027116","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T20:25:32Z","timestamp":1545683132000},"page":"619-624","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":64,"title":["Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors"],"prefix":"10.1073","volume":"116","author":[{"given":"Charles","family":"Li","sequence":"first","affiliation":[{"name":"Department of Genetics, Yale School of Medicine, New Haven, CT 06510;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bonazzoli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; 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