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A normal function of HTT is that of a scaffold for selective autophagy, a mechanism of protein and organelle degradation by the lysosome required for neuronal health. Here, we show that the inflammatory I\u03baB kinase (IKK) kinase subunit IKK\u03b2 may function in vivo to regulate autophagy through direct phosphorylation of HTT at serine 13 and through the activation of autophagy gene expression. IKK\u03b2 is required to slow HD behavioral progression and to suppress neurodegeneration and microglial activation in HD transgenic mice. Our work suggests that the early activation of IKK may be protective to activate autophagy, thereby slowing HD progression.<\/jats:p>","DOI":"10.1073\/pnas.1814246116","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T18:18:10Z","timestamp":1557857890000},"page":"10952-10961","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["IKK\u03b2 slows Huntington\u2019s disease progression in R6\/1 mice"],"prefix":"10.1073","volume":"116","author":[{"given":"Joseph","family":"Ochaba","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Behavior, University of California, Irvine, CA 92697;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna","family":"Fote","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, University of California, Irvine, CA 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