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However, the nature of the dynamic coupling between microscale cell and ECM mechanics remains poorly understood. Here we investigate whether cells mechanically adapt to distinct microenvironments. We determined that tumor cells are mechanically plastic to adapt to many environments. This mechanical mismatch holds for multiple perturbations of the cytoskeletal architecture and in 2 different surrogate ECM hydrogels mimicking breast and brain microenvironments. Our data also obey laws similar to those used to model rheological properties of polymers. Linking these mathematical parameters to biophysical factors will move us closer to exploiting mechanics as a cancer biomarker.<\/jats:p>","DOI":"10.1073\/pnas.1814271116","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T17:16:02Z","timestamp":1562087762000},"page":"14448-14455","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":73,"title":["High-frequency microrheology in 3D reveals mismatch between cytoskeletal and extracellular matrix mechanics"],"prefix":"10.1073","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-8025","authenticated-orcid":false,"given":"Jack R.","family":"Staunton","sequence":"first","affiliation":[{"name":"Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong 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