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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2018,12,18]]},"abstract":"<jats:p>Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine cancers. SVV mediates cell entry by attachment to the receptor anthrax toxin receptor 1 (ANTXR1). Here we determine atomic structures of mature SVV particles alone and in complex with ANTXR1 in both neutral and acidic conditions, as well as empty \u201cspent\u201d particles in complex with ANTXR1 in acidic conditions by cryoelectron microscopy. SVV engages ANTXR1 mainly by the VP2 DF and VP1 CD loops, leading to structural changes in the VP1 GH loop and VP3 GH loop, which attenuate interprotomer interactions and destabilize the capsid assembly. Despite lying on the edge of the attachment site, VP2 D146 interacts with the metal ion in ANTXR1 and is required for cell entry. Though the individual substitution of most interacting residues abolishes receptor binding and virus propagation, a serine-to-alanine mutation at VP2 S177 significantly increases SVV proliferation. Acidification of the SVV\u2013ANTXR1 complex results in a major reconfiguration of the pentameric capsid assemblies, which rotate \u223c20\u00b0 around the icosahedral fivefold axes to form a previously uncharacterized spent particle resembling a potential uncoating intermediate with remarkable perforations at both two- and threefold axes. These structures provide high-resolution snapshots of SVV entry, highlighting opportunities for anticancer therapeutic optimization.<\/jats:p>","DOI":"10.1073\/pnas.1814309115","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T16:25:33Z","timestamp":1543940733000},"page":"13087-13092","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":51,"title":["Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1"],"prefix":"10.1073","volume":"115","author":[{"given":"Lin","family":"Cao","sequence":"first","affiliation":[{"name":"Drug Discovery Center for Infectious Disease, College of Pharmacy, Nankai University, 300071 Tianjin, China;"},{"name":"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070 Hubei, China;"},{"name":"College of Life Sciences, Nankai University, 300071 Tianjin, 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J Natl Cancer Inst 99, 1623\u20131633 (2007).","journal-title":"J Natl Cancer Inst"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/pbc.22535","article-title":"Initial testing of the replication competent Seneca Valley virus (NTX-010) by the pediatric preclinical testing program","volume":"55","author":"Morton CL","year":"2010","unstructured":"CL Morton, , Initial testing of the replication competent Seneca Valley virus (NTX-010) by the pediatric preclinical testing program. Pediatr Blood Cancer 55, 295\u2013303 (2010).","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/jnci\/djt130","article-title":"Selective tropism of Seneca Valley virus for variant subtype small cell lung cancer","volume":"105","author":"Poirier JT","year":"2013","unstructured":"JT Poirier, , Selective tropism of Seneca Valley virus for variant subtype small cell lung cancer. J Natl Cancer Inst 105, 1059\u20131065 (2013).","journal-title":"J Natl Cancer Inst"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1172\/JCI93472","article-title":"Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus","volume":"127","author":"Miles LA","year":"2017","unstructured":"LA Miles, , Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus. J Clin Invest 127, 2957\u20132967 (2017).","journal-title":"J Clin Invest"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","article-title":"Identification of the cellular receptor for anthrax toxin","volume":"414","author":"Bradley KA","year":"2001","unstructured":"KA Bradley, J Mogridge, M Mourez, RJ Collier, JA Young, Identification of the cellular receptor for anthrax toxin. 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