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We also show that\n                    <jats:italic>Smcr8<\/jats:italic>\n                    and\n                    <jats:italic>Wdr41<\/jats:italic>\n                    mutations sensitize mice to chemically induced colitis. Our findings reveal an important negative regulatory mechanism that limits endosomal TLR signaling and shed light on the mechanism by which deficiencies of C9ORF72 or SMCR8 cause inflammation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1814753115","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T17:28:22Z","timestamp":1542302902000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":60,"title":["Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function"],"prefix":"10.1073","volume":"115","author":[{"given":"William","family":"McAlpine","sequence":"first","affiliation":[{"name":"Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 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