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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,2,26]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Human cytomegalovirus (HCMV) causes severe morbidity and mortality in immunocompromised patients and is the most commonly transmitted virus that causes developmental defects in the fetus. Currently, there is no licensed HCMV vaccine available, and prior efforts using attenuated viruses and subunit vaccines were not successful. Recently, there has been intense interest in the HCMV pentamer glycoprotein as a component of vaccines. Here, we show that transplant patients\u2019 and pregnant mothers\u2019 sera contain neutralizing antibodies specific for the pentamer and also for a second HCMV glycoprotein, the trimer, which is essential for HCMV entry into cells. Trimer- and pentamer-specific antibodies acted synergistically to neutralize virus and block cell\u2013cell spread. These observations will have major implications for the future of HCMV vaccine development.<\/jats:p>","DOI":"10.1073\/pnas.1814835116","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T20:39:22Z","timestamp":1549571962000},"page":"3728-3733","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":60,"title":["HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission"],"prefix":"10.1073","volume":"116","author":[{"given":"Adam L.","family":"Vanarsdall","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology &amp; Immunology, Oregon Health &amp; Science University, Portland, OR 97239;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology &amp; Immunology, Oregon Health &amp; Science 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