{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:13:33Z","timestamp":1791918813431,"version":"4.3.4"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"8","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHL1936\/3-4"],"award-info":[{"award-number":["SCHL1936\/3-4"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["unknown (to DS)"],"award-info":[{"award-number":["unknown (to DS)"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,2,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    This paper describes a pathway for anaerobic bacterial metabolism of taurine (2-aminoethanesulfonate), an abundant substrate in the human intestinal microbiota, by the intestinal bacterium and opportunistic pathogen,\n                    <jats:italic>Bilophila wadsworthia<\/jats:italic>\n                    . This metabolism converts taurine to the toxic metabolite hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), an activity associated with inflammatory bowel disease and colorectal cancer. A critical enzyme in this pathway is isethionate sulfite-lyase, a member of the glycyl radical enzyme family. This enzyme catalyzes a novel, radical-based C-S bond-cleavage reaction to convert isethionate (2-hydroxyethanesulfonate) to sulfite and acetaldehyde. This discovery improves our understanding of H\n                    <jats:sub>2<\/jats:sub>\n                    S production in the human body and may also offer new approaches for controlling intestinal H\n                    <jats:sub>2<\/jats:sub>\n                    S production and\n                    <jats:italic>B. wadsworthia<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1815661116","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T20:43:14Z","timestamp":1549312994000},"page":"3171-3176","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":194,"title":["A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium\n                    <i>Bilophila wadsworthia<\/i>"],"prefix":"10.1073","volume":"116","author":[{"given":"Spencer C.","family":"Peck","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Denger","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Konstanz, D-78457 Konstanz, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Burrichter","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Konstanz, D-78457 Konstanz, Germany;"},{"name":"Konstanz Research School Chemical Biology, University of Konstanz, D-78457 Konstanz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephania M.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily P.","family":"Balskus","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schleheck","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Konstanz, D-78457 Konstanz, Germany;"},{"name":"Konstanz Research School Chemical Biology, University of Konstanz, D-78457 Konstanz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00448"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms3040866"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/em.20546","article-title":"DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells","volume":"51","author":"Attene-Ramos MS","year":"2010","unstructured":"MS Attene-Ramos, , DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells. 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