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U.S.A."],"published-print":{"date-parts":[[2019,1,29]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Mitochondria are the primary source of ATP for placental growth, transport, and hormone synthesis. However, to date, little is known about the developmental regulation or functional significance of placental mitochondria during normal or suboptimal intrauterine conditions, such as oxygen deprivation (hypoxia). Here we show that, in the placenta, mitochondria adapt their use of oxygen and nutrients (carbohydrate and fat) to best support both placental growth and function, as well as fetal development, during normal and hypoxic conditions. These data are significant because they improve our mechanistic understanding of human pregnancies compromised by fetal growth restriction at sea level and high altitude.<\/jats:p>","DOI":"10.1073\/pnas.1816056116","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T22:07:09Z","timestamp":1547762829000},"page":"1621-1626","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":113,"title":["Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth"],"prefix":"10.1073","volume":"116","author":[{"given":"Amanda N.","family":"Sferruzzi-Perri","sequence":"first","affiliation":[{"name":"Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3EG Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine 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