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U.S.A."],"published-print":{"date-parts":[[2018,12,11]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    PIEZOs are mechanically activated cation channels. Recently, loss-of-function mutations of human\n                    <jats:italic>PIEZO1<\/jats:italic>\n                    were found among patients with familial lymphedema, suggesting a requirement of PIEZO1 in the lymphatic system. In this paper, utilizing mouse models lacking PIEZO1 in endothelial cells, we show that this ion channel is required for the formation of lymphatic valves, a key structure for proper circulation of lymph in the body. The requirement of PIEZO1 in valve formation provides mechanistic insight on how\n                    <jats:italic>PIEZO1<\/jats:italic>\n                    variants cause lymphatic dysfunction in patients. This study also extends the relevance of PIEZOs beyond acute signaling molecules (e.g., touch sensation) and highlights the importance of these ion channels in controlling morphological\/structural specification during development.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1817070115","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T17:55:44Z","timestamp":1543341344000},"page":"12817-12822","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":286,"title":["Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation"],"prefix":"10.1073","volume":"115","author":[{"given":"Keiko","family":"Nonomura","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, The Scripps Research Institute, La Jolla, CA 92037;"},{"name":"Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 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