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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,4,23]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    A number of multimeric protein nanomachines such as secretion systems and surface appendages allow bacteria to adapt and survive in a variety of environments. Type IV pili are one of the most common of such machineries. The human pathogen\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    uses type IV pili to colonize blood vessels and cause disease. Here, we identify compounds that trigger the rapid retraction of type IV pili. Furthermore, we identify the target of these small molecules as an ATPase known as PilF among the 20 proteins involved in pilus assembly and function. This study paves the way for an innovative treatment strategy for different pathogens and provides information on the molecular mechanisms driving the assembly and dynamics of bacterial machineries.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1817757116","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T19:49:01Z","timestamp":1554407341000},"page":"8481-8486","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":50,"title":["Inhibitors of the\n                    <i>Neisseria meningitidis<\/i>\n                    PilF ATPase provoke type IV pilus disassembly"],"prefix":"10.1073","volume":"116","author":[{"given":"Flore","family":"Aubey","sequence":"first","affiliation":[{"name":"Pathogenesis of Vascular Infections, Department of Cell Biology and Infection, Institut Pasteur, INSERM, 75015 Paris, 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