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U.S.A."],"published-print":{"date-parts":[[2018,12,26]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    This work shows that the amidated terminal ends of the secreted hypocretin (HCRT) peptides (HCRT\n                    <jats:sub>NH2<\/jats:sub>\n                    ) are autoantigens in type 1 narcolepsy, an autoimmune disorder targeting HCRT neurons. The autoimmune process is usually initiated by influenza A flu infections, and a particular piece of the hemagglutinin (HA) flu protein of the pandemic 2009 H1N1 strain was identified as a likely trigger. This HA epitope has homology with HCRT\n                    <jats:sub>NH2<\/jats:sub>\n                    and T cells cross-reactive to both epitopes are involved in the autoimmune process by molecular mimicry. Genes associated with narcolepsy mark the particular HLA heterodimer (DQ0602) involved in presentation of these antigens and modulate expression of the specific T cell receptor segments (TRAJ24 and TRBV4-2) involved in T cell receptor recognition of these antigens, suggesting causality.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1818150116","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T21:45:22Z","timestamp":1544651122000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":185,"title":["Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy"],"prefix":"10.1073","volume":"115","author":[{"given":"Guo","family":"Luo","sequence":"first","affiliation":[{"name":"Center for Sleep Sciences and Medicine, Stanford University School of Medicine, Palo Alto, CA 94304;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Ambati","sequence":"additional","affiliation":[{"name":"Center for Sleep Sciences and Medicine, Stanford University School of Medicine, Palo Alto, CA 94304;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Sleep Sciences and Medicine, Stanford University School of Medicine, Palo Alto, CA 94304;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lodie","family":"Bonvalet","sequence":"additional","affiliation":[{"name":"Center for Sleep Sciences and Medicine, Stanford University School of Medicine, Palo Alto, CA 94304;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Partinen","sequence":"additional","affiliation":[{"name":"Helsinki Sleep Clinic, Vitalmed Research Centre, 00380 Helsinki, Finland;"},{"name":"Department of Clinical Neurosciences, University of Helsinki, 00100 Helsinki, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhuai","family":"Ji","sequence":"additional","affiliation":[{"name":"Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Palo Alto, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holden Terry","family":"Maecker","sequence":"additional","affiliation":[{"name":"Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Palo Alto, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel Jean-Marie","family":"Mignot","sequence":"additional","affiliation":[{"name":"Center for Sleep Sciences and Medicine, Stanford University School of Medicine, Palo Alto, CA 94304;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003880"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003270"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.734"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.647"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.372"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.12.010"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr2569w"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.02.003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.8.979"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22587"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2016.12.005"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12391"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12355"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114361"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05582-8"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/79690"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00058-1"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007762"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.05.001"},{"key":"e_1_3_3_20_2","first-page":"zsw070","article-title":"CD4+ T-cell reactivity to orexin\/hypocretin in patients with narcolepsy type 1","volume":"40","author":"Ramberger M","year":"2017","unstructured":"M Ramberger, , CD4+ T-cell reactivity to orexin\/hypocretin in patients with narcolepsy type 1. 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