{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:26:18Z","timestamp":1793147178212,"version":"4.5.0"},"reference-count":30,"publisher":"National Academy of Sciences","issue":"2","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,1,8]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    It is known that nutrient starvation stimulates mitochondrial fusion for cell survival. In this study, a homozygous mutation in the\n                    <jats:italic>NME3<\/jats:italic>\n                    gene, which encodes an NDP kinase, was identified in a fatal neurodegenerative disorder. Cells derived from the patient were deficient of NME3 and intolerant to glucose starvation. Patient cells were used to demonstrate that NME3 rescued cell survival by two separate functions, namely stimulation of mitochondrial fusion and NDP kinase activity. Since mitochondrial dynamics and energy efficiency are important for neuronal development, our data suggest a link between two functions of NME3 and a fatal neuronal disorder.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1818629116","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T19:45:14Z","timestamp":1545853514000},"page":"566-574","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":57,"title":["Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder"],"prefix":"10.1073","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-4820","authenticated-orcid":false,"given":"Chih-Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Molecular Medicine, College of Medicine, National Taiwan University, 10002 Taipei, 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