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U.S.A."],"published-print":{"date-parts":[[2019,8,6]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Small organelles such as endoplasmic reticulum (ER) and mitochondria play key roles in cellular functions and survival. Furthermore, physical tethering between ER\u2013mitochondria allows communication between these 2 organelles, and proteins involved in the contact sites have been identified in various cells. However, physiological significances of ER\u2013mitochondria contacts in axons are unknown. Here, we discover that Grp75 mRNA is locally translated in injured axonal tips. Up-regulation of Grp75 promotes ER\u2013mitochondria tethering and enhances axon regeneration in vitro. Increased levels ofGrp75 in dorsal root ganglion neurons facilitates axon regeneration and functional recovery of animals with nerve injury. 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