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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,3,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    TIM proteins inhibit release of HIV-1 and other enveloped viruses. However, it is currently unknown whether and how the virus counteracts this restriction. In this work, we demonstrate that Nef proteins of HIV-1 and other lentiviruses function as antagonists to overcome the TIM-mediated restriction. TIM-1 is more potent at inhibiting release of Nef-deficient HIV-1 relative to wild-type (WT) HIV-1, and ectopic expression of Nef relieves this restriction. Interestingly, we find that SERINC proteins potentiate TIM-mediated inhibition of HIV-1 release likely by stabilizing TIM-1 expression. Our work reveals a role for lentiviral\n                    <jats:italic>Nef<\/jats:italic>\n                    in antagonizing TIMs, in part through SERINCs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1819475116","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T19:34:15Z","timestamp":1551900855000},"page":"5705-5714","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":33,"title":["TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins"],"prefix":"10.1073","volume":"116","author":[{"given":"Minghua","family":"Li","sequence":"first","affiliation":[{"name":"Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210;"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul A.","family":"Waheed","sequence":"additional","affiliation":[{"name":"Virus\u2013Cell Interaction Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyou","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210;"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210;"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Min","family":"Zheng","sequence":"additional","affiliation":[{"name":"Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210;"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Feizpour","sequence":"additional","affiliation":[{"name":"Department of Chemistry and The Photonics Center, Boston University, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn M.","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Department of Chemistry and The Photonics Center, Boston University, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-8481","authenticated-orcid":false,"given":"Suryaram","family":"Gummuluru","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Boston University School of Medicine, Boston, MA 02118;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric O.","family":"Freed","sequence":"additional","affiliation":[{"name":"Virus\u2013Cell Interaction Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210;"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210;"},{"name":"Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210;"},{"name":"Viruses and Emerging Pathogens Thematic Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1111"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2010.00903.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2003.09.011"},{"key":"e_1_3_3_4_2","first-page":"201","article-title":"TIM gene family and their role in atopic diseases","volume":"321","author":"Umetsu DT","year":"2008","unstructured":"DT Umetsu, SE Umetsu, GJ Freeman, RH DeKruyff, TIM gene family and their role in atopic diseases. 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