{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:14:28Z","timestamp":1790846068179,"version":"4.1.0"},"reference-count":29,"publisher":"National Academy of Sciences","issue":"19","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,5,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Multiple myeloma (MM) is one of the most common hematological malignancies. Developing an effective treatment strategy for refractory\/relapsed (R\/R) MM represents a major challenge. In this trial, 17 R\/R MM patients, who had previously experienced multiple lines of treatments, received a chimeric antigen receptor modified T (CAR T) cell preparation targeting two epitopes of BCMA, and a remarkable overall response of 88.2% was achieved. This work confirms the feasibility and importance of CAR T cell therapy in the treatment of patients with R\/R MM. Meanwhile, the adverse events encountered in this study are analyzed, providing a reference for other studies. We also suggest that CAR T treatment can eventually be combined with other effective therapeutics to treat newly diagnosed MM for achieving a better result in future trials.<\/jats:p>","DOI":"10.1073\/pnas.1819745116","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T20:26:00Z","timestamp":1555359960000},"page":"9543-9551","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":358,"title":["Exploratory trial of a biepitopic CAR T-targeting B cell maturation antigen in relapsed\/refractory multiple myeloma"],"prefix":"10.1073","volume":"116","author":[{"given":"Jie","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, 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