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Genome editing revealed\n                    <jats:italic>Fgr<\/jats:italic>\n                    dependency of the inflammatory phenotype in\n                    <jats:italic>Ali18<\/jats:italic>\n                    mice. Further, whole exome sequencing in our CRMO cohort identified two patients with missense mutations in\n                    <jats:italic>FGR<\/jats:italic>\n                    . In vitro functional assays confirm altered protein function. This work identifies\n                    <jats:italic>FGR<\/jats:italic>\n                    as a CRMO susceptibility gene and suggests that targeting SFKs may be useful in its treatment.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1819825116","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T17:24:35Z","timestamp":1559064275000},"page":"11872-11877","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":39,"title":["Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans"],"prefix":"10.1073","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2026-0171","authenticated-orcid":false,"given":"Koichiro","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Molecular Life Science, Tokai University School of Medicine, Isehara 259-1193, Kanagawa, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, IA 52242;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"School of Science, Kitasato University, Sagamihara 252-0373, Kanagawa, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Velez","sequence":"additional","affiliation":[{"name":"Omics Laboratory, Byers Eye Institute, Stanford University, Palo Alto, CA 94304;"},{"name":"Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Laxer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital for Sick Children, University of Toronto, ON M5G 1X8, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley M. 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