{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:08:55Z","timestamp":1792343335006,"version":"4.4.0"},"reference-count":16,"publisher":"National Academy of Sciences","issue":"21","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,5,21]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Long-duration spaceflight induces detrimental changes in human physiology due to microgravity. One example is a cephalic fluid shift. Here, we prospectively investigated the quantitative changes in cerebrospinal fluid (CSF) volume of the brain ventricular regions in space crew by means of a region of interest, observer-independent analysis on structural brain MRI scans. MRI scans were collected before the mission, shortly after and 7 mo after return to Earth. We found a significant increase in lateral and third ventricles at postflight and a trend to normalization at follow-up, but still significantly increased ventricular volumes. The observed spatiotemporal pattern of CSF compartment enlargement and recovery points to a reduced CSF resorption in microgravity as the underlying cause.<\/jats:p>","DOI":"10.1073\/pnas.1820354116","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T13:05:52Z","timestamp":1557234352000},"page":"10531-10536","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":148,"title":["Brain ventricular volume changes induced by long-duration spaceflight"],"prefix":"10.1073","volume":"116","author":[{"given":"Angelique","family":"Van Ombergen","sequence":"first","affiliation":[{"name":"Lab for Equilibrium Investigations and Aerospace, University of Antwerp, 2610 Antwerp, Belgium;"},{"name":"Department of Translational Neurosciences, University of Antwerp, 2610 Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Jillings","sequence":"additional","affiliation":[{"name":"Lab for Equilibrium Investigations and Aerospace, University of Antwerp, 2610 Antwerp, Belgium;"},{"name":"Coma Science Group, GIGA Research, Neurology Department, University and University Hospital of Li\u00e8ge, 4000 Li\u00e8ge, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Jeurissen","sequence":"additional","affiliation":[{"name":"Imec\/Vision Lab, University of Antwerp, 2610 Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Tomilovskaya","sequence":"additional","affiliation":[{"name":"State Science Center of the Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Rumshiskaya","sequence":"additional","affiliation":[{"name":"Radiology Department, Federal Center of Treatment and Rehabilitation, 125367 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudmila","family":"Litvinova","sequence":"additional","affiliation":[{"name":"Radiology Department, Federal Center of Treatment and Rehabilitation, 125367 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Nosikova","sequence":"additional","affiliation":[{"name":"State Science Center of the Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Pechenkova","sequence":"additional","affiliation":[{"name":"Laboratory for Cognitive Research, National Research University, Higher School of Economics, 101000 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Rukavishnikov","sequence":"additional","affiliation":[{"name":"State Science Center of the Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Manko","sequence":"additional","affiliation":[{"name":"State Science Center of the Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Danylichev","sequence":"additional","affiliation":[{"name":"Gagarin Cosmonauts Training Center, 141160 Star City, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Maxine","family":"R\u00fchl","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inessa B.","family":"Kozlovskaya","sequence":"additional","affiliation":[{"name":"State Science Center of the Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sunaert","sequence":"additional","affiliation":[{"name":"Translational MRI, Department of Imaging &amp; Pathology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Parizel","sequence":"additional","affiliation":[{"name":"Radiology Department, Antwerp University Hospital and University of Antwerp, 2650 Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Sinitsyn","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Medicine, Lomonosov Moscow State University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Laureys","sequence":"additional","affiliation":[{"name":"Coma Science Group, GIGA Research, Neurology Department, University and University Hospital of Li\u00e8ge, 4000 Li\u00e8ge, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sijbers","sequence":"additional","affiliation":[{"name":"Imec\/Vision Lab, University of Antwerp, 2610 Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"zu Eulenburg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris L.","family":"Wuyts","sequence":"additional","affiliation":[{"name":"Lab for Equilibrium Investigations and Aerospace, University of Antwerp, 2610 Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9905-4_2"},{"key":"e_1_3_3_2_2","first-page":"621","article-title":"Microgravity-induced fluid shift and ophthalmic changes","volume":"4","author":"Nelson ES","year":"2014","unstructured":"Nelson ES, Mulugeta L, Myers JG (2014) Microgravity-induced fluid shift and ophthalmic changes. 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