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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,6,11]]},"abstract":"<jats:p>\n                    Caspase-8 is a key integrator of cell survival and cell death decisions during infection and inflammation. Following engagement of tumor necrosis factor superfamily receptors or certain Toll-like receptors (TLRs), caspase-8 initiates cell-extrinsic apoptosis while inhibiting RIPK3-dependent programmed necrosis. In addition, caspase-8 has an important, albeit less well understood, role in cell-intrinsic inflammatory gene expression. Macrophages lacking caspase-8 or the adaptor FADD have defective inflammatory cytokine expression and inflammasome priming in response to bacterial infection or TLR stimulation. How caspase-8 regulates cytokine gene expression, and whether caspase-8\u2013mediated gene regulation has a physiological role during infection, remain poorly defined. Here we demonstrate that both caspase-8 enzymatic activity and scaffolding functions contribute to inflammatory cytokine gene expression. Caspase-8 enzymatic activity was necessary for maximal expression of\n                    <jats:italic>Il1b<\/jats:italic>\n                    and\n                    <jats:italic>Il12b<\/jats:italic>\n                    , but caspase-8 deficient cells exhibited a further decrease in expression of these genes. Furthermore, the ability of TLR stimuli to induce optimal I\u03baB kinase phosphorylation and nuclear translocation of the nuclear factor kappa light chain enhancer of activated B cells family member c-Rel required caspase activity. Interestingly, overexpression of c-Rel was sufficient to restore expression of IL-12 and IL-1\u03b2 in caspase-8\u2013deficient cells. Moreover,\n                    <jats:italic>Ripk3<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>Casp8<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice were unable to control infection by the intracellular parasite\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    , which corresponded to defects in monocyte recruitment to the peritoneal cavity, and exogenous IL-12 restored monocyte recruitment and protection of caspase-8\u2013deficient mice during acute toxoplasmosis. These findings provide insight into how caspase-8 controls inflammatory gene expression and identify a critical role for caspase-8 in host defense against eukaryotic pathogens.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1820529116","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T20:45:24Z","timestamp":1559249124000},"page":"11926-11935","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":61,"title":["Caspase-8 promotes c-Rel\u2013dependent inflammatory cytokine expression and resistance against\n                    <i>Toxoplasma gondii<\/i>"],"prefix":"10.1073","volume":"116","author":[{"given":"Alexandra A.","family":"DeLaney","sequence":"first","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104;"},{"name":"Cell and Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corbett T.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104;"},{"name":"School of Biomedical Engineering, Drexel University College of Medicine, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Christian","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hart","sequence":"additional","affiliation":[{"name":"Immunology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Bjanes","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104;"},{"name":"Cell and Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan A.","family":"Wynosky-Dolfi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Tummers","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina A.","family":"Udalova","sequence":"additional","affiliation":[{"name":"Kennedy Institute of Rheumatology, Medical Sciences Division, University of Oxford, OX3 9DU Oxford, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhai H.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Hershberg","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Drexel University College of Medicine, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104;"},{"name":"Cell and Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Immunology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104;"},{"name":"Cell and Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Immunology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7970-872X","authenticated-orcid":false,"given":"Igor E.","family":"Brodsky","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104;"},{"name":"Cell and Molecular Biology Graduate Group, Perelman School of Medicine at the University 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