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The approach should be broadly applicable to other repeat expansion diseases and to any multivalent oligomeric therapeutic agent whose activity can accommodate structural elements that mimic cell-penetrating peptides.<\/jats:p>","DOI":"10.1073\/pnas.1820827116","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T15:16:21Z","timestamp":1555427781000},"page":"8709-8714","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1"],"prefix":"10.1073","volume":"116","author":[{"given":"JuYeon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, IL 61801;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugang","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Nanomedicine, Hunan University, Changsha, 410082 Hunan, China;"},{"name":"State Key Laboratory of Chemo\/Biosensing and Chemometrics, Hunan University, Changsha, 410082 Hunan, China;"},{"name":"Department of Chemistry, Hunan University, Changsha, 410082 Hunan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ullas V.","family":"Chembazhi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois at Urbana\u2013Champaign, Urbana, IL 61801;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohong","family":"Peng","sequence":"additional","affiliation":[{"name":"Laboratory of Drosophila Research, School of Life Sciences, The Chinese University of Hong Kong, Shatin N.T., Hong Kong Special Administrative Region, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Yum","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois at Urbana\u2013Champaign, Urbana, IL 61801;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long M.","family":"Luu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, IL 61801;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren D.","family":"Hagler","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, IL 61801;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio F.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Illinois at Urbana\u2013Champaign, Urbana, IL 61801;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4307-474X","authenticated-orcid":false,"given":"H. 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