{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:32:19Z","timestamp":1792794739609,"version":"4.5.0"},"reference-count":45,"publisher":"National Academy of Sciences","issue":"19","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,9,17]]},"abstract":"<jats:p>\n                    The 2,160,267 bp genome sequence of\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    <jats:italic>agalactiae<\/jats:italic>\n                    , the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes. Genome comparisons among\n                    <jats:italic>S. agalactiae<\/jats:italic>\n                    ,\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    ,\n                    <jats:italic>Streptococcus pyogenes<\/jats:italic>\n                    , and the other completely sequenced genomes identified genes specific to the streptococci and to\n                    <jats:italic>S. agalactiae<\/jats:italic>\n                    . These\n                    <jats:italic>in silico<\/jats:italic>\n                    analyses, combined with comparative genome hybridization experiments between the sequenced serotype V strain 2603 V\/R and 19\n                    <jats:italic>S. agalactiae<\/jats:italic>\n                    strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among\n                    <jats:italic>S. agalactiae<\/jats:italic>\n                    strains, even of the same serotype, and provided insights into the evolution of virulence mechanisms.\n                  <\/jats:p>","DOI":"10.1073\/pnas.182380799","type":"journal-article","created":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T12:40:55Z","timestamp":1032266455000},"page":"12391-12396","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":437,"title":["Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V\n                    <i>Streptococcus agalactiae<\/i>"],"prefix":"10.1073","volume":"99","author":[{"given":"Herv\u00e9","family":"Tettelin","sequence":"first","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Immunological Research Institute Siena, Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy; Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115; Harvard Medical School, Boston, MA 02115; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037; and Division of Infectious Diseases..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vega","family":"Masignani","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Immunological Research Institute Siena, Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy; Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115; Harvard Medical School, Boston, MA 02115; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037; and Division of Infectious Diseases..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Cieslewicz","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Immunological Research Institute Siena, Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy; Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115; Harvard Medical School, Boston, MA 02115; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037; and Division of Infectious Diseases..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Eisen","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Immunological Research Institute Siena, Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy; Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115; Harvard Medical School, Boston, MA 02115; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037; and Division of Infectious Diseases..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Peterson","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Immunological Research Institute Siena, Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy; Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115; Harvard Medical School, Boston, MA 02115; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037; and Division of Infectious Diseases..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Wessels","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Immunological Research Institute Siena, Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy; Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115; Harvard Medical School, Boston, MA 02115; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037; and Division of Infectious Diseases..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian T.","family":"Paulsen","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Immunological Research Institute Siena, Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy; Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115; Harvard Medical School, Boston, MA 02115; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037; 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