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However, careful molecular comparison of the mutant spectra of several genomic segments suggests that the largest increases in mutation frequency do not predict virus extinction. Highly mutated viral genomes have escaped detection presumably because lymphocytic choriomeningitis virus replicates at or near the error threshold, and genomes in the transition toward error catastrophe may have an extremely short half-life and escape detection with state-of-the-art cloning and sequencing technologies.<\/jats:p>","DOI":"10.1073\/pnas.182426999","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T12:58:28Z","timestamp":1033477108000},"page":"12938-12943","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":130,"title":["Molecular indetermination in the transition to error catastrophe: Systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity"],"prefix":"10.1073","volume":"99","author":[{"given":"A.","family":"Grande-P\u00e9rez","sequence":"first","affiliation":[{"name":"Molecular Medicine and Gene Therapy Unit, Department of Medicine, University of Manchester, Manchester M13 9PT, United Kingdom; Centro de Biolog\u00eda Molecular Severo Ochoa, Universidad Aut\u00f3noma de Madrid, Cantoblanco, 28049 Madrid, Spain; Gene Therapeutics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048; and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sierra","sequence":"additional","affiliation":[{"name":"Molecular Medicine and Gene Therapy Unit, Department of Medicine, University of Manchester, Manchester M13 9PT, United Kingdom; Centro de Biolog\u00eda Molecular Severo Ochoa, Universidad Aut\u00f3noma de Madrid, Cantoblanco, 28049 Madrid, Spain; Gene Therapeutics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048; and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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