{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:47:08Z","timestamp":1791308828647,"version":"4.3.1"},"reference-count":31,"publisher":"National Academy of Sciences","issue":"19","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,9,16]]},"abstract":"<jats:p>\n                    Different components of the AP1 transcription factor complex appear to have distinct effects on cell proliferation and transformation. In contrast to other AP1 components, JunD has been shown to inhibit cell proliferation. Also, in prior studies, JunD alone bound menin, product of the\n                    <jats:italic>MEN1<\/jats:italic>\n                    tumor suppressor gene, and JunD's transcriptional activity was inhibited by menin, suggesting that JunD might achieve all or most of its unique properties through binding to menin. Analyses of JunD and menin effects on proliferation, morphology, and cyclin D1 in stable cell lines unmasked an unexpected growth promoting activity of JunD. Whereas stable overexpression of wild-type (wt) mouse JunD in\n                    <jats:italic>JunD<\/jats:italic>\n                    <jats:sup>\u2013<\/jats:sup>\n                    <jats:sup>\/<\/jats:sup>\n                    <jats:sup>\u2013<\/jats:sup>\n                    immortalized fibroblasts inhibited their proliferation and reverted their transformed-like phenotype, overexpression of a missense mouse JunD mutant (mJunD\n                    <jats:sup>G42E<\/jats:sup>\n                    ) with disabled binding to menin showed opposite or growth promoting effects. Similarly, stable overexpression of wt mouse JunD in wt immortalized fibroblasts inhibited growth. In contrast, its overexpression in\n                    <jats:italic>Men1<\/jats:italic>\n                    <jats:sup>\u2013<\/jats:sup>\n                    <jats:sup>\/<\/jats:sup>\n                    <jats:sup>\u2013<\/jats:sup>\n                    immortalized fibroblasts enhanced their already transformed-like characteristics. To conclude, JunD changed from growth suppressor to growth promoter when its binding to menin was prevented by a JunD mutant unable to bind menin or by\n                    <jats:italic>Men1<\/jats:italic>\n                    -null genetic background.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1834524100","type":"journal-article","created":{"date-parts":[[2003,9,16]],"date-time":"2003-09-16T13:42:33Z","timestamp":1063719753000},"page":"10770-10775","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":116,"title":["Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter"],"prefix":"10.1073","volume":"100","author":[{"given":"Sunita K.","family":"Agarwal","sequence":"first","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; Unit of Gene Expression and Disease, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e 1644, Department of Developmental Biology, Institut Pasteur, 75015 Paris France; and Molecular Pathophysiology Section, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Novotny","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; Unit of Gene Expression and Disease, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e 1644, Department of Developmental Biology, Institut Pasteur, 75015 Paris France; and Molecular Pathophysiology Section, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy S.","family":"Crabtree","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; Unit of Gene Expression and Disease, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e 1644, Department of Developmental Biology, Institut Pasteur, 75015 Paris France; and Molecular Pathophysiology Section, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B.","family":"Weitzman","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; Unit of Gene Expression and Disease, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e 1644, Department of Developmental Biology, Institut Pasteur, 75015 Paris France; and Molecular Pathophysiology Section, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Yaniv","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; Unit of Gene Expression and Disease, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e 1644, Department of Developmental Biology, Institut Pasteur, 75015 Paris France; and Molecular Pathophysiology Section, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Lee","family":"Burns","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; Unit of Gene Expression and Disease, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e 1644, Department of Developmental Biology, Institut Pasteur, 75015 Paris France; and Molecular Pathophysiology Section, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Settara C.","family":"Chandrasekharappa","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; Unit of Gene Expression and Disease, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e 1644, Department of Developmental Biology, Institut Pasteur, 75015 Paris France; and Molecular Pathophysiology Section, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis S.","family":"Collins","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; Unit of Gene Expression and Disease, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e 1644, Department of Developmental Biology, Institut Pasteur, 75015 Paris France; and Molecular Pathophysiology Section, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen M.","family":"Spiegel","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; Unit of Gene Expression and Disease, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e 1644, Department of Developmental Biology, Institut Pasteur, 75015 Paris France; and Molecular Pathophysiology Section, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Marx","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; Unit of Gene Expression and Disease, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e 1644, Department of Developmental Biology, Institut Pasteur, 75015 Paris France; and Molecular Pathophysiology Section, National..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,9,5]]},"reference":[{"key":"e_1_3_2_1_2","unstructured":"Angel P. E. & Herrlich P. A. (1994) in The Fos and Jun Family of Transcription Factors eds. Angel P. E. & Herrlich P. A. (CRC Boca Raton FL) pp. 3\u201314."},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204389"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204383"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80967-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(99)00132-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5311.404"},{"key":"e_1_3_2_7_2","unstructured":"Marx S. J. (2002) in The Genetic Basis of Human Cancer eds. Vogelstein B. & Kinzler K. W. (McGraw\u2013Hill New York) pp. 475\u2013450."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00509-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00430-6"},{"key":"e_1_3_2_11_2","first-page":"4706","volume":"41","year":"2000","unstructured":"Knapp, J. I., Heppner, C., Hickman, A. B., Burns, A. L., Chandrasekharappa, S. C., Collins, F. S., Marx, S. J., Spiegel, A. M. & Agarwal, S. K. (2000) Oncogene 41, 4706\u20134712.","journal-title":"Oncogene"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90513-4"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.20.8890"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.5.607"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00109-X"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng790"},{"key":"e_1_3_2_17_2","first-page":"143","volume":"127","year":"2000","unstructured":"Thepot, D., Weitzman, J. B., Barra, J., Segretain, D., Stinnakre, M. G., Babinet, C. & Yaniv, M. (2000) Development (Cambridge, U.K.) 127, 143\u2013153.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1118"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.4.1630"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0897-375"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(74)90457-7"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9331"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.9.2056"},{"key":"e_1_3_2_24_2","first-page":"561","volume":"6","year":"1991","unstructured":"Berger, I. & Shaul, Y. (1991) Oncogene 6, 561\u2013566.1903194","journal-title":"Oncogene"},{"key":"e_1_3_2_25_2","first-page":"2509","volume":"11","year":"1995","unstructured":"Bannister, A. J., Oehler, T., Wilhelm, D., Angel, P. & Kouzarides, T. (1995) Oncogene 11, 2509\u20132514.8545107","journal-title":"Oncogene"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3050967"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/383453a0"},{"key":"e_1_3_2_28_2","first-page":"916","volume":"61","year":"2001","unstructured":"Yazgan, O. & Pfarr, C. M. (2001) Cancer Res. 61, 916\u2013920.11221882","journal-title":"Cancer Res."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205822"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10885"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.40.23589"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1834524100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T21:31:01Z","timestamp":1650922261000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1834524100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,5]]},"references-count":31,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2003,9,16]]}},"alternative-id":["10.1073\/pnas.1834524100"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1834524100","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,5]]},"assertion":[{"value":"2003-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}