{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:50:55Z","timestamp":1782517855626,"version":"3.54.5"},"reference-count":64,"publisher":"National Academy of Sciences","issue":"33","license":[{"start":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T00:00:00Z","timestamp":1579910400000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"name":"DKFZ- MOST","award":["-"],"award-info":[{"award-number":["-"]}]},{"name":"ERA-NET","award":["JTC 2014-project FIRE-CLL"],"award-info":[{"award-number":["JTC 2014-project FIRE-CLL"]}]},{"name":"Binational Science Foundation","award":["711979"],"award-info":[{"award-number":["711979"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,8,13]]},"abstract":"<jats:p>\n                    SLAMF9 belongs to the conserved lymphocytic activation molecule family (SLAMF). Unlike other SLAMs, which have been extensively studied, the role of SLAMF9 in the immune system remained mostly unexplored. By generating CRISPR\/Cas9 SLAMF9 knockout mice, we analyzed the role of this receptor in plasmacytoid dendritic cells (pDCs), which preferentially express the SLAMF9 transcript and protein. These cells display a unique capacity to produce type I IFN and bridge between innate and adaptive immune response. Analysis of pDCs in SLAMF9\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice revealed an increase of immature pDCs in the bone marrow and enhanced accumulation of pDCs in the lymph nodes. In the periphery, SLAMF9 deficiency resulted in lower levels of the transcription factor SpiB, elevation of pDC survival, and attenuated IFN-\u03b1 and TNF-\u03b1 production. To define the role of SLAMF9 during inflammation, pDCs lacking SLAMF9 were followed during induced experimental autoimmune encephalomyelitis. SLAMF9\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice demonstrated attenuated disease and delayed onset, accompanied by a prominent increase of immature pDCs in the lymph node, with a reduced costimulatory potential and enhanced infiltration of pDCs into the central nervous system. These results suggest the crucial role of SLAMF9 in pDC differentiation, homeostasis, and function in the steady state and during experimental autoimmune encephalomyelitis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1900079116","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T19:45:23Z","timestamp":1564083923000},"page":"16489-16496","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":27,"title":["SLAMF9 regulates pDC homeostasis and function in health and disease"],"prefix":"10.1073","volume":"116","author":[{"given":"Lital","family":"Sever","sequence":"first","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihi","family":"Radomir","sequence":"additional","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Stirm","sequence":"additional","affiliation":[{"name":"Department of Chronic Inflammation and Cancer, German Cancer Research Center, 69120 Heidelberg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wiener","sequence":"additional","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nofar","family":"Schottlender","sequence":"additional","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadas","family":"Lewinsky","sequence":"additional","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avital F.","family":"Barak","sequence":"additional","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilgi","family":"Friedlander","sequence":"additional","affiliation":[{"name":"Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, 76100 Rehovot, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-1939","authenticated-orcid":false,"given":"Shifra","family":"Ben-Dor","sequence":"additional","affiliation":[{"name":"Life Science Core Facilities, Department of Biochemistry, Weizmann Institute of Science, 76100 Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirly","family":"Becker-Herman","sequence":"additional","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idit","family":"Shachar","sequence":"additional","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nri2456","article-title":"SLAM receptors and SAP influence lymphocyte interactions, development and function","volume":"9","author":"Schwartzberg P. L.","year":"2009","unstructured":"P. L. Schwartzberg, K. L. Mueller, H. Qi, J. L. Cannons, SLAM receptors and SAP influence lymphocyte interactions, development and function. Nat. Rev. Immunol. 9, 39\u201346 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"10583","DOI":"10.1073\/pnas.0703893104","article-title":"Structure of CD84 provides insight into SLAM family function","volume":"104","author":"Yan Q.","year":"2007","unstructured":"Q. Yan ., Structure of CD84 provides insight into SLAM family function. Proc. Natl. Acad. Sci. U.S.A. 104, 10583\u201310588 (2007).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1146\/annurev-immunol-030409-101302","article-title":"SLAM family receptors and SAP adaptors in immunity","volume":"29","author":"Cannons J. L.","year":"2011","unstructured":"J. L. Cannons, S. G. Tangye, P. L. Schwartzberg, SLAM family receptors and SAP adaptors in immunity. Annu. Rev. Immunol. 29, 665\u2013705 (2011).","journal-title":"Annu. Rev. Immunol."},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1749-6632.2010.05824.x","article-title":"The role of SAP and SLAM family molecules in the humoral immune response","volume":"1217","author":"Ma C. S.","year":"2011","unstructured":"C. S. Ma, E. K. Deenick, The role of SAP and SLAM family molecules in the humoral immune response. Ann. N. Y. Acad. Sci. 1217, 32\u201344 (2011).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"e_1_3_4_5_2","first-page":"822s","article-title":"Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1, a novel CD84 homologue","volume":"7","author":"Zhang W.","year":"2001","unstructured":"W. Zhang ., Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1, a novel CD84 homologue. Clin. Cancer Res. 7 (suppl. 3), 822s\u2013829s (2001).","journal-title":"Clin. Cancer Res."},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s002510100364","article-title":"CD2F-10: A new member of the CD2 subset of the immunoglobulin superfamily","volume":"53","author":"Fennelly J. A.","year":"2001","unstructured":"J. A. Fennelly, B. Tiwari, S. J. Davis, E. J. Evans, CD2F-10: A new member of the CD2 subset of the immunoglobulin superfamily. Immunogenetics 53, 599\u2013602 (2001).","journal-title":"Immunogenetics"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00251-001-0415-7","article-title":"Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM\/CD2 family","volume":"53","author":"Fraser C. C.","year":"2002","unstructured":"C. C. Fraser ., Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM\/CD2 family. Immunogenetics 53, 843\u2013850 (2002).","journal-title":"Immunogenetics"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-018-0191-z"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.immunol.23.021704.115633","article-title":"IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors","volume":"23","author":"Liu Y. J.","year":"2005","unstructured":"Y. J. Liu, IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 23, 275\u2013306 (2005).","journal-title":"Annu. Rev. Immunol."},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1126\/science.284.5421.1835","article-title":"The nature of the principal type 1 interferon-producing cells in human blood","volume":"284","author":"Siegal F. P.","year":"1999","unstructured":"F. P. Siegal ., The nature of the principal type 1 interferon-producing cells in human blood. Science 284, 1835\u20131837 (1999).","journal-title":"Science"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.immuni.2010.11.020","article-title":"Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual","volume":"33","author":"Swiecki M.","year":"2010","unstructured":"M. Swiecki, S. Gilfillan, W. Vermi, Y. Wang, M. Colonna, Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual. Immunity 33, 955\u2013966 (2010).","journal-title":"Immunity"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1182\/blood-2002-10-3186","article-title":"CD8alpha+ mouse spleen dendritic cells do not originate from the CD8alpha- dendritic cell subset","volume":"102","author":"Naik S.","year":"2003","unstructured":"S. Naik, D. Vremec, L. Wu, M. O\u2019Keeffe, K. Shortman, CD8alpha+ mouse spleen dendritic cells do not originate from the CD8alpha- dendritic cell subset. Blood 102, 601\u2013604 (2003).","journal-title":"Blood"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/ni1518","article-title":"Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow","volume":"8","author":"Onai N.","year":"2007","unstructured":"N. Onai ., Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat. Immunol. 8, 1207\u20131216 (2007).","journal-title":"Nat. Immunol."},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.immuni.2004.06.011","article-title":"Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin","volume":"21","author":"Shigematsu H.","year":"2004","unstructured":"H. Shigematsu ., Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity 21, 43\u201353 (2004).","journal-title":"Immunity"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41590-018-0136-9","article-title":"Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells","volume":"19","author":"Rodrigues P. F.","year":"2018","unstructured":"P. F. Rodrigues ., Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells. Nat. Immunol. 19, 711\u2013722 (2018).","journal-title":"Nat. Immunol."},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.it.2010.05.004","article-title":"Trafficking properties of plasmacytoid dendritic cells in health and disease","volume":"31","author":"Sozzani S.","year":"2010","unstructured":"S. Sozzani, W. Vermi, A. Del Prete, F. Facchetti, Trafficking properties of plasmacytoid dendritic cells in health and disease. Trends Immunol. 31, 270\u2013277 (2010).","journal-title":"Trends Immunol."},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nri3027","article-title":"Plasmacytoid dendritic cells: One-trick ponies or workhorses of the immune system?","volume":"11","author":"Reizis B.","year":"2011","unstructured":"B. Reizis, M. Colonna, G. Trinchieri, F. Barrat, M. Gilliet, Plasmacytoid dendritic cells: One-trick ponies or workhorses of the immune system? Nat. Rev. Immunol. 11, 558\u2013565 (2011).","journal-title":"Nat. Rev. Immunol."},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nri3865","article-title":"The multifaceted biology of plasmacytoid dendritic cells","volume":"15","author":"Swiecki M.","year":"2015","unstructured":"M. Swiecki, M. Colonna, The multifaceted biology of plasmacytoid dendritic cells. Nat. Rev. Immunol. 15, 471\u2013485 (2015).","journal-title":"Nat. Rev. Immunol."},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2008.09.016","article-title":"Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development","volume":"135","author":"Cisse B.","year":"2008","unstructured":"B. Cisse ., Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 135, 37\u201348 (2008).","journal-title":"Cell"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.immuni.2010.11.023","article-title":"Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells","volume":"33","author":"Ghosh H. S.","year":"2010","unstructured":"H. S. Ghosh, B. Cisse, A. Bunin, K. L. Lewis, B. Reizis, Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity 33, 905\u2013916 (2010).","journal-title":"Immunity"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1182\/blood-2012-06-436527","article-title":"Spi-B is critical for plasmacytoid dendritic cell function and development","volume":"120","author":"Sasaki I.","year":"2012","unstructured":"I. Sasaki ., Spi-B is critical for plasmacytoid dendritic cell function and development. Blood 120, 4733\u20134743 (2012).","journal-title":"Blood"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1084\/jem.20080718","article-title":"Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC","volume":"205","author":"Tai L. H.","year":"2008","unstructured":"L. H. Tai ., Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC. J. Exp. Med. 205, 3187\u20133199 (2008).","journal-title":"J. Exp. Med."},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"6657","DOI":"10.4049\/jimmunol.174.11.6657","article-title":"Development of murine plasmacytoid dendritic cells defined by increased expression of an inhibitory NK receptor, Ly49Q","volume":"174","author":"Omatsu Y.","year":"2005","unstructured":"Y. Omatsu ., Development of murine plasmacytoid dendritic cells defined by increased expression of an inhibitory NK receptor, Ly49Q. J. Immunol. 174, 6657\u20136662 (2005).","journal-title":"J. Immunol."},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1073\/pnas.0710351105","article-title":"PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon","volume":"105","author":"Watarai H.","year":"2008","unstructured":"H. Watarai ., PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon. Proc. Natl. Acad. Sci. U.S.A. 105, 2993\u20132998 (2008).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_4_25_2","first-page":"2123","article-title":"[Recent experience in: Saving the inferior mesenteric artery during anterior resection of the rectum] [in Italian]","volume":"44","author":"Borioni R.","year":"1989","unstructured":"R. Borioni, G. Lavanga, M. Garofalo, R. Garofalo, [Recent experience in: Saving the inferior mesenteric artery during anterior resection of the rectum] [in Italian]. Minerva Chir. 44, 2123 (1989).","journal-title":"Minerva Chir."},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1084\/jem.20090547","article-title":"Regulation of TLR7\/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction","volume":"206","author":"Cao W.","year":"2009","unstructured":"W. Cao ., Regulation of TLR7\/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J. Exp. Med. 206, 1603\u20131614 (2009).","journal-title":"J. Exp. Med."},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cellimm.2010.06.005","article-title":"BDCA-2 signaling inhibits TLR-9-agonist-induced plasmacytoid dendritic cell activation and antigen presentation","volume":"265","author":"J\u00e4hn P. S.","year":"2010","unstructured":"P. S. J\u00e4hn, K. S. Z\u00e4nker, J. Schmitz, A. Dzionek, BDCA-2 signaling inhibits TLR-9-agonist-induced plasmacytoid dendritic cell activation and antigen presentation. Cell. Immunol. 265, 15\u201322 (2010).","journal-title":"Cell. Immunol."},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.cell.2013.04.025","article-title":"One-step generation of mice carrying mutations in multiple genes by CRISPR\/Cas-mediated genome engineering","volume":"153","author":"Wang H.","year":"2013","unstructured":"H. Wang ., One-step generation of mice carrying mutations in multiple genes by CRISPR\/Cas-mediated genome engineering. Cell 153, 910\u2013918 (2013).","journal-title":"Cell"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran F. A.","year":"2013","unstructured":"F. A. Ran ., Genome engineering using the CRISPR-Cas9 system. Nat. Protoc. 8, 2281\u20132308 (2013).","journal-title":"Nat. Protoc."},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nmeth.3473","article-title":"Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach","volume":"12","author":"Chari R.","year":"2015","unstructured":"R. Chari, P. Mali, M. Moosburner, G. M. Church, Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach. Nat. Methods 12, 823\u2013826 (2015).","journal-title":"Nat. Methods"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1101\/gr.191452.115","article-title":"Sequence determinants of improved CRISPR sgRNA design","volume":"25","author":"Xu H.","year":"2015","unstructured":"H. Xu ., Sequence determinants of improved CRISPR sgRNA design. Genome Res. 25, 1147\u20131157 (2015).","journal-title":"Genome Res."},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent W. J.","year":"2002","unstructured":"W. J. Kent ., The human genome browser at UCSC. Genome Res. 12, 996\u20131006 (2002).","journal-title":"Genome Res."},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014A Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders S.","year":"2015","unstructured":"S. Anders, P. T. Pyl, W. Huber, HTSeq\u2014A Python framework to work with high-throughput sequencing data. Bioinformatics 31, 166\u2013169 (2015).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love M. I.","year":"2014","unstructured":"M. I. Love, W. Huber, S. Anders, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ni1008-1091","article-title":"The immunological genome project: Networks of gene expression in immune cells","volume":"9","author":"Heng T. S.","year":"2008","unstructured":"T. S. Heng, M. W. Painter; Immunological Genome Project Consortium, The immunological genome project: Networks of gene expression in immune cells. Nat. Immunol. 9, 1091\u20131094 (2008).","journal-title":"Nat. Immunol."},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1182\/blood-2008-03-143370","article-title":"Congenic interval of CD45\/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment","volume":"115","author":"Waterstrat A.","year":"2010","unstructured":"A. Waterstrat, Y. Liang, C. F. Swiderski, B. J. Shelton, G. Van Zant, Congenic interval of CD45\/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment. Blood 115, 408\u2013417 (2010).","journal-title":"Blood"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.stemcr.2016.04.010","article-title":"Single targeted exon mutation creates a true congenic mouse for competitive hematopoietic stem cell transplantation: The C57BL\/6-CD45.1(STEM) mouse","volume":"6","author":"Mercier F. E.","year":"2016","unstructured":"F. E. Mercier, D. B. Sykes, D. T. Scadden, Single targeted exon mutation creates a true congenic mouse for competitive hematopoietic stem cell transplantation: The C57BL\/6-CD45.1(STEM) mouse. Stem Cell Rep. 6, 985\u2013992 (2016).","journal-title":"Stem Cell Rep."},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1084\/jem.20130443","article-title":"Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells","volume":"210","author":"Sawai C. M.","year":"2013","unstructured":"C. M. Sawai ., Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells. J. Exp. Med. 210, 2151\u20132159 (2013).","journal-title":"J. Exp. Med."},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1182\/blood-2004-09-3388","article-title":"Ly49Q defines 2 pDC subsets in mice","volume":"105","author":"Kamogawa-Schifter Y.","year":"2005","unstructured":"Y. Kamogawa-Schifter ., Ly49Q defines 2 pDC subsets in mice. Blood 105, 2787\u20132792 (2005).","journal-title":"Blood"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"6562","DOI":"10.1182\/blood-2010-12-326678","article-title":"Identification of CCR9- murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs","volume":"117","author":"Schlitzer A.","year":"2011","unstructured":"A. Schlitzer ., Identification of CCR9- murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs. Blood 117, 6562\u20136570 (2011).","journal-title":"Blood"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1182\/blood-2005-09-3842","article-title":"Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors","volume":"107","author":"Zhang J.","year":"2006","unstructured":"J. Zhang ., Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Blood 107, 3600\u20133608 (2006).","journal-title":"Blood"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1002\/eji.201343498","article-title":"Sca-1 expression defines developmental stages of mouse pDCs that show functional heterogeneity in the endosomal but not lysosomal TLR9 response","volume":"43","author":"Niederquell M.","year":"2013","unstructured":"M. Niederquell ., Sca-1 expression defines developmental stages of mouse pDCs that show functional heterogeneity in the endosomal but not lysosomal TLR9 response. Eur. J. Immunol. 43, 2993\u20133005 (2013).","journal-title":"Eur. J. Immunol."},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/1521-4141(200107)31:7<2154::AID-IMMU2154>3.0.CO;2-U","article-title":"Identification of CpG oligonucleotide sequences with high induction of IFN-alpha\/beta in plasmacytoid dendritic cells","volume":"31","author":"Krug A.","year":"2001","unstructured":"A. Krug ., Identification of CpG oligonucleotide sequences with high induction of IFN-alpha\/beta in plasmacytoid dendritic cells. Eur. J. Immunol. 31, 2154\u20132163 (2001).","journal-title":"Eur. J. Immunol."},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.4049\/jimmunol.173.3.1535","article-title":"Regulation of IFN regulatory factor-7 and IFN-alpha production by enveloped virus and lipopolysaccharide in human plasmacytoid dendritic cells","volume":"173","author":"Dai J.","year":"2004","unstructured":"J. Dai, N. J. Megjugorac, S. B. Amrute, P. Fitzgerald-Bocarsly, Regulation of IFN regulatory factor-7 and IFN-alpha production by enveloped virus and lipopolysaccharide in human plasmacytoid dendritic cells. J. Immunol. 173, 1535\u20131548 (2004).","journal-title":"J. Immunol."},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/ni.2535","article-title":"OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7","volume":"14","author":"Lee M. S.","year":"2013","unstructured":"M. S. Lee, B. Kim, G. T. Oh, Y. J. Kim, OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7. Nat. Immunol. 14, 346\u2013355 (2013).","journal-title":"Nat. Immunol."},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ni1243","article-title":"IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction","volume":"6","author":"Kawai T.","year":"2005","unstructured":"T. Kawai ., IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6, 981\u2013988 (2005).","journal-title":"Nat. Immunol."},{"key":"e_1_3_4_47_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature04734","article-title":"Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses","volume":"441","author":"Kato H.","year":"2006","unstructured":"H. Kato ., Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441, 101\u2013105 (2006).","journal-title":"Nature"},{"key":"e_1_3_4_48_2","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/ni.1932","article-title":"IFI16 is an innate immune sensor for intracellular DNA","volume":"11","author":"Unterholzner L.","year":"2010","unstructured":"L. Unterholzner ., IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 11, 997\u20131004 (2010).","journal-title":"Nat. Immunol."},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.immuni.2006.08.010","article-title":"Type I interferon in systemic lupus erythematosus and other autoimmune diseases","volume":"25","author":"Banchereau J.","year":"2006","unstructured":"J. Banchereau, V. Pascual, Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25, 383\u2013392 (2006).","journal-title":"Immunity"},{"key":"e_1_3_4_50_2","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nri2358","article-title":"Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases","volume":"8","author":"Gilliet M.","year":"2008","unstructured":"M. Gilliet, W. Cao, Y. J. Liu, Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8, 594\u2013606 (2008).","journal-title":"Nat. Rev. Immunol."},{"key":"e_1_3_4_51_2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/NEN.0b013e31816fc975","article-title":"Plasmacytoid dendritic cells in multiple sclerosis: Intracerebral recruitment and impaired maturation in response to interferon-beta","volume":"67","author":"Lande R.","year":"2008","unstructured":"R. Lande ., Plasmacytoid dendritic cells in multiple sclerosis: Intracerebral recruitment and impaired maturation in response to interferon-beta. J. Neuropathol. Exp. Neurol. 67, 388\u2013401 (2008).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"e_1_3_4_52_2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ni1430","article-title":"CNS myeloid DCs presenting endogenous myelin peptides \u2018preferentially\u2019 polarize CD4+ T(H)-17 cells in relapsing EAE","volume":"8","author":"Bailey S. L.","year":"2007","unstructured":"S. L. Bailey, B. Schreiner, E. J. McMahon, S. D. Miller, CNS myeloid DCs presenting endogenous myelin peptides \u2018preferentially\u2019 polarize CD4+ T(H)-17 cells in relapsing EAE. Nat. Immunol. 8, 172\u2013180 (2007).","journal-title":"Nat. Immunol."},{"key":"e_1_3_4_53_2","first-page":"Unit 15.1","article-title":"Experimental autoimmune encephalomyelitis in the mouse","volume":"15","author":"Miller S. D.","year":"2010","unstructured":"S. D. Miller, W. J. Karpus, T. S. Davidson, Experimental autoimmune encephalomyelitis in the mouse. Curr. Protoc. Immunol. Chapter 15, Unit 15.1 (2010).","journal-title":"Curr. Protoc. Immunol."},{"key":"e_1_3_4_54_2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/brain\/124.3.480","article-title":"Two subsets of dendritic cells are present in human cerebrospinal fluid","volume":"124","author":"Pashenkov M.","year":"2001","unstructured":"M. Pashenkov ., Two subsets of dendritic cells are present in human cerebrospinal fluid. Brain 124, 480\u2013492 (2001).","journal-title":"Brain"},{"key":"e_1_3_4_55_2","doi-asserted-by":"crossref","first-page":"10050","DOI":"10.1128\/JVI.01692-16","article-title":"Cell-cell sensing of viral infection by plasmacytoid dendritic cells","volume":"90","author":"Webster B.","year":"2016","unstructured":"B. Webster, S. Assil, M. Dreux, Cell-cell sensing of viral infection by plasmacytoid dendritic cells. J. Virol. 90, 10050\u201310053 (2016).","journal-title":"J. Virol."},{"key":"e_1_3_4_56_2","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.4049\/jimmunol.1301022","article-title":"Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56(dim) NK cells","volume":"191","author":"Hagberg N.","year":"2013","unstructured":"N. Hagberg ., Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56(dim) NK cells. J. Immunol. 191, 2989\u20132998 (2013).","journal-title":"J. Immunol."},{"key":"e_1_3_4_57_2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/s41419-018-1011-1","article-title":"The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration","volume":"9","author":"Dollt C.","year":"2018","unstructured":"C. Dollt ., The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration. Cell Death Dis. 9, 939 (2018).","journal-title":"Cell Death Dis."},{"key":"e_1_3_4_58_2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fimmu.2015.00158","article-title":"Negative regulation of humoral immunity due to interplay between the SLAMF1, SLAMF5, and SLAMF6 receptors","volume":"6","author":"Wang N.","year":"2015","unstructured":"N. Wang ., Negative regulation of humoral immunity due to interplay between the SLAMF1, SLAMF5, and SLAMF6 receptors. Front. Immunol. 6, 158 (2015).","journal-title":"Front. Immunol."},{"key":"e_1_3_4_59_2","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1084\/jem.20110654","article-title":"Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo","volume":"208","author":"Swiecki M.","year":"2011","unstructured":"M. Swiecki ., Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo. J. Exp. Med. 208, 2367\u20132374 (2011).","journal-title":"J. Exp. Med."},{"key":"e_1_3_4_60_2","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1002\/eji.1830241038","article-title":"CD2-CD48 interaction prevents apoptosis in murine B lymphocytes by up-regulating bcl-2 expression","volume":"24","author":"Genaro A. M.","year":"1994","unstructured":"A. M. Genaro, J. A. Gonzalo, L. Bosca, C. Martinez, CD2-CD48 interaction prevents apoptosis in murine B lymphocytes by up-regulating bcl-2 expression. Eur. J. Immunol. 24, 2515\u20132521 (1994).","journal-title":"Eur. J. Immunol."},{"key":"e_1_3_4_61_2","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.1417620112","article-title":"Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells","volume":"112","author":"Carrington E. M.","year":"2015","unstructured":"E. M. Carrington ., Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 112, 4044\u20134049 (2015).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_4_62_2","doi-asserted-by":"crossref","first-page":"6457","DOI":"10.4049\/jimmunol.180.10.6457","article-title":"Cutting edge: Central nervous system plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune encephalomyelitis","volume":"180","author":"Bailey-Bucktrout S. L.","year":"2008","unstructured":"S. L. Bailey-Bucktrout ., Cutting edge: Central nervous system plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune encephalomyelitis. J. Immunol. 180, 6457\u20136461 (2008).","journal-title":"J. Immunol."},{"key":"e_1_3_4_63_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jaut.2015.08.014","article-title":"pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation","volume":"67","author":"Duraes F. V.","year":"2016","unstructured":"F. V. Duraes ., pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation. J. Autoimmun. 67, 8\u201318 (2016).","journal-title":"J. Autoimmun."},{"key":"e_1_3_4_64_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bbi.2010.01.014","article-title":"Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis","volume":"24","author":"Murphy A. C.","year":"2010","unstructured":"A. C. Murphy, S. J. Lalor, M. A. Lynch, K. H. Mills, Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis. Brain Behav. Immun. 24, 641\u2013651 (2010).","journal-title":"Brain Behav. Immun."}],"updated-by":[{"DOI":"10.1073\/pnas.1914890116","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000}}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1900079116","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1900079116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T15:52:40Z","timestamp":1654617160000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1900079116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":64,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2019,8,13]]}},"alternative-id":["10.1073\/pnas.1900079116"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1900079116","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]},"assertion":[{"value":"2019-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}