{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:34:46Z","timestamp":1793108086630,"version":"4.5.0"},"reference-count":79,"publisher":"National Academy of Sciences","issue":"17","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,4,23]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The primary finding in this study was the dramatic primary association of brain resting-state network (RSN) connectivity abnormalities with a history of childhood trauma in major depressive disorder (MDD). Even though participants in this study were not selected for a history of trauma and the brain imaging took place decades after trauma occurrence, the scar of prior trauma was evident in functional dysconnectivity. In addition to childhood trauma, dimensions of MDD symptoms were related to abnormal network connectivity. Further, we found that a network model of MDD described within- and between-network connectivity differences from controls in multiple RSNs, including the default mode network, frontoparietal network, and attention and sensory systems.<\/jats:p>","DOI":"10.1073\/pnas.1900801116","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T20:27:42Z","timestamp":1554755262000},"page":"8582-8590","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":221,"title":["Childhood trauma history is linked to abnormal brain connectivity in major depression"],"prefix":"10.1073","volume":"116","author":[{"given":"Meichen","family":"Yu","sequence":"first","affiliation":[{"name":"Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin A.","family":"Linn","sequence":"additional","affiliation":[{"name":"Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell T.","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desmond J.","family":"Oathes","sequence":"additional","affiliation":[{"name":"Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Cook","sequence":"additional","affiliation":[{"name":"Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Duprat","sequence":"additional","affiliation":[{"name":"Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1384-0151","authenticated-orcid":false,"given":"Tyler M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Brain and Behavior Laboratory, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Oquendo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin","family":"McInnis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Michigan School of Medicine, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Fava","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhukar H.","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Center for Depression Research and Clinical Care, Peter O'Donnell Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"McGrath","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University College of Physicians &amp; Surgeons, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Parsey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Stony Brook University, Stony Brook, NY 11794;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrna M.","family":"Weissman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University College of Physicians &amp; Surgeons, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette I.","family":"Sheline","sequence":"additional","affiliation":[{"name":"Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"},{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20128"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-031912-114409"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01491.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.65"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60602-8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4502"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.09.016"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00579-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.02.003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10101419"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.09.020"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000446107"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.04.004"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-014030"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2015.10.002"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.76"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0071"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0217-264d"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt290"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.09.028"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0201-7"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4125"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.006"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157243"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.14050594"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.04.003"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.165"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.08.006"},{"key":"e_1_3_3_31_2","unstructured":"; US Department of Health & Human Services Child Maltreatment 2009 (US Government Printing Office Washington DC) Report 20. (2009)."},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-7435(03)00123-3"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.06.021"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2018.01.004"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.04.012"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715766115"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800376105"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.03.008"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1364.060"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712002942"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.02.016"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503436112"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811168106"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.027"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.06.022"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.033"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.111"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3470"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1017\/pen.2018.8"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3940"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbtep.2014.09.005"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000118"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.014"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.09.005"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.169"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2016.08.003"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2206"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.0669"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.66"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16080883"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2008.01.001"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858414525995"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn755"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812686106"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.11.024"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502829112"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24241"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.03.020"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0065-y"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.08.052"},{"key":"e_1_3_3_72_2","doi-asserted-by":"crossref","unstructured":"TD Satterthwaite Motion artifact in studies of functional connectivity: Characteristics and mitigation strategies. Hum Brain Mapp 10.1002\/hbm.23665. (November 1 2017).","DOI":"10.1002\/hbm.23665"},{"key":"e_1_3_3_73_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","unstructured":"Y Benjamini, Y Hochberg, Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc 57, 289\u2013300 (1995).","journal-title":"J R Stat Soc"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1109\/TIT.1982.1056489"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(02)00541-0"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1971.10482356"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/32.1.29"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1080\/00221300009598588"}],"updated-by":[{"DOI":"10.1073\/pnas.1908918116","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000}}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1900801116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T14:51:44Z","timestamp":1721141504000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1900801116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":79,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2019,4,23]]}},"alternative-id":["10.1073\/pnas.1900801116"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1900801116","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,8]]},"assertion":[{"value":"2019-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}