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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,6,4]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Muscle-wasting diseases are due in part to improper regulation of mRNA stability. Mutations in the mRNA decay protein AUF1 are linked to a specific form of muscle-wasting disease known as limb girdle muscular dystrophy that affects the muscles of the limbs and torso. How AUF1 is involved in regulating or promoting muscle regeneration is largely unknown. Here, we demonstrate that AUF1 controls all of the major stages of muscle development and regeneration, from control of the muscle stem (satellite) cell differentiation program through the development of mature muscle fibers, by selectively targeting for rapid degradation the major differentiation checkpoint mRNAs that block entry into each next phase of muscle development, thereby promoting each stage of muscle development.<\/jats:p>","DOI":"10.1073\/pnas.1901165116","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T18:05:20Z","timestamp":1558461920000},"page":"11285-11290","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":34,"title":["Muscle development and regeneration controlled by AUF1-mediated stage-specific degradation of fate-determining checkpoint mRNAs"],"prefix":"10.1073","volume":"116","author":[{"given":"Dounia","family":"Abbadi","sequence":"first","affiliation":[{"name":"Department of Microbiology, New York University School of Medicine, New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, New York University School of Medicine, New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon M.","family":"Chenette","sequence":"additional","affiliation":[{"name":"Department of Microbiology, New York University School of Medicine, New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Microbiology, New York University School of Medicine, New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5807-5564","authenticated-orcid":false,"given":"Robert J.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Microbiology, New York University School of Medicine, New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)89102-1"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1230"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.5142"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1467606"},{"key":"e_1_3_3_5_2","first-page":"42","article-title":"Exercise, skeletal muscle and inflammation: ARE-binding proteins as key regulators in inflammatory and adaptive networks","volume":"21","author":"Beiter T.","year":"2015","unstructured":"T. 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