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In this study, we provide mechanistic insights on mirabegron-triggered atherosclerosis in causing potential cardiovascular and cerebrovascular diseases by activation of brown fat. Given that mirabegron can induce brown fat activation in adult human subjects, these findings are clinically relevant. Moreover, genetic mutations of low-density lipoprotein receptor (LDLR) frequently occur in human populations (1 in 300 humans carries LDLR mutations). If this population of patients receive mirabegron therapy, it would be of a high risk. This important issue has not been explored in clinical studies, and warrants further investigation.<\/jats:p>","DOI":"10.1073\/pnas.1901655116","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T20:25:40Z","timestamp":1557779140000},"page":"10937-10942","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":71,"title":["Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis"],"prefix":"10.1073","volume":"116","author":[{"given":"Wenhai","family":"Sui","sequence":"first","affiliation":[{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, 250012 Jinan, 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