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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,12,3]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Our study provides significant advances in the understanding of circulating exosomal microRNA (miRNA) in animals. Circulating exosomal miRNAs mediate communication among tissues and organs. In glia, mature miR-274 is produced and secreted to the circulating hemolymph to target the recipient cells, neurons, and tracheal cells. We also identified the target gene\n                    <jats:italic>sty<\/jats:italic>\n                    whose expression is down-regulated by miR-274 in the target\/recipient cells. Downregulation of Sty leads to upregulation of MAPK signaling, thereby promoting the growth of synaptic boutons and tracheal branches. Thus, glia-derived miR-274 might be deemed a \u201cgliotransmitter\u201d to mediate communication with neurons and tracheal cells. The modulation of tracheal branches by glial-derived miR-274 is also crucial for fine-tuning larval behavior in response to hypoxia.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1902537116","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T19:25:16Z","timestamp":1572463516000},"page":"24651-24661","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and responses to hypoxia"],"prefix":"10.1073","volume":"116","author":[{"given":"Yi-Wei","family":"Tsai","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology, Academia Sinica, 11529 Taipei, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Ho","family":"Sung","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Academia Sinica, 11529 Taipei, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Chiuan","family":"Li","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35053 Zhunan, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yen","family":"Yeh","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Academia Sinica, 11529 Taipei, Taiwan;"},{"name":"Taiwan International Graduate Program in Interdisciplinary Neuroscience, National Cheng Kung University and Academia Sinica, 11529 Taipei, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Academia Sinica, 11529 Taipei, Taiwan;"},{"name":"Institute of Neuroscience, National Yang-Ming University, 11221 Taipei, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ju","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Academia Sinica, 11529 Taipei, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35053 Zhunan, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Life Science, Tunghai University, 40704 Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Ting","family":"Chien","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Academia Sinica, 11529 Taipei, Taiwan;"},{"name":"Taiwan International Graduate Program in Interdisciplinary Neuroscience, National Cheng Kung University and Academia Sinica, 11529 Taipei, Taiwan;"},{"name":"Institute of Neuroscience, National Yang-Ming University, 11221 Taipei, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2595-9"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126516"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.125"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3410\/B3-15"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3838"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1285"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov244"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21365"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.08.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4137\/GEI.S38147"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03875"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-152829"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.028845"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.322904"},{"key":"e_1_3_3_15_2","first-page":"11","article-title":"Cerebral oxygen delivery and consumption during evoked neural activity","volume":"2","author":"Vazquez A. 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