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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    As a critical component of a healthy memory management system, forgetting has received increasing attention. Studies across multiple species support important roles of actin remodeling in forgetting. However, the underlying molecular mechanisms remain unclear. In\n                    <jats:italic>Drosophila<\/jats:italic>\n                    , Rac1 and Cdc42, 2 Rho GTPases that act as signaling hubs to coordinate actin remodeling, were reported to mediate the forgetting of labile and consolidated memories, respectively. Here, we showed that Rac1 and Cdc42 exert their effects on forgetting by acting through 2 different actin polymerization pathways, Rac1\/SCAR\/Dia and Cdc42\/WASp\/Arp2\/3 complexes. These findings fill in the molecular landscape that link forgetting to actin remodeling at the cellular level and shed light on drug development that aims to tune forgetting to treat memory-related diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1903763116","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T17:45:47Z","timestamp":1567705547000},"page":"21191-21197","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":41,"title":["Genetic dissection of active forgetting in labile and consolidated memories in\n                    <i>Drosophila<\/i>"],"prefix":"10.1073","volume":"116","author":[{"given":"Yang","family":"Gao","sequence":"first","affiliation":[{"name":"Tsinghua-Peking Center for Life Sciences, McGovern Institute for Brain Research, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, 100084 Beijing, 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