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Here, we lay out a general approach for optimizing inhibition strategies based on small molecules that suppress nucleation or growth of aggregates. Our model reveals that the optimal timing of drug administration crucially depends on whether the compound inhibits primary nucleation, secondary nucleation, or the growth of aggregates. This approach could guide the rational design of therapeutic strategies to target protein aggregation diseases.<\/jats:p>","DOI":"10.1073\/pnas.1904090116","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T20:15:29Z","timestamp":1561752929000},"page":"14593-14598","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["Optimal control strategies for inhibition of protein aggregation"],"prefix":"10.1073","volume":"116","author":[{"given":"Thomas C. 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